KMS88009 | CAS#1089681-42-4 | aggregation inhibitor

MedKoo Cat#: 563006 | Name: KMS88009

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KMS88009 is an inhibitor of amyloid-β aggregation. It acts by ameliorating the neurodegenerative disorder.

Chemical Structure

KMS88009

CAS#1089681-42-4

Theoretical Analysis

MedKoo Cat#: 563006

Name: KMS88009

CAS#: 1089681-42-4

Chemical Formula: C19H19NO2

Exact Mass: 293.1416

Molecular Weight: 293.36

Elemental Analysis: C, 77.79; H, 6.53; N, 4.77; O, 10.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

KMS88009; KMS-88009; KMS 88009;

IUPAC/Chemical Name

(E)-6-Methoxy-2-(4-dimethylaminostyryl) benzofuran

InChi Key

GAAPZOXKUKNOPB-UXBLZVDNSA-N

InChi Code

InChI=1S/C19H19NO2/c1-20(2)16-8-4-14(5-9-16)6-10-18-12-15-7-11-17(21-3)13-19(15)22-18/h4-13H,1-3H3/b10-6+

SMILES Code

CN(C1=CC=C(C=C1)/C=C/C2=CC3=CC=C(OC)C=C3O2)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 293.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Brener O, Dunkelmann T, Gremer L, van Groen T, Mirecka EA, Kadish I, Willuweit A, Kutzsche J, Jürgens D, Rudolph S, Tusche M, Bongen P, Pietruszka J, Oesterhelt F, Langen KJ, Demuth HU, Janssen A, Hoyer W, Funke SA, Nagel-Steger L, Willbold D. QIAD assay for quantitating a compound's efficacy in elimination of toxic Aβ oligomers. Sci Rep. 2015 Sep 23;5:13222. doi: 10.1038/srep13222. PubMed PMID: 26394756; PubMed Central PMCID: PMC4585794. 2: Lee SH, Kim Y, Kim HY, Kim YH, Kim MS, Kong JY, Lee MH, Kim DJ, Ahn YG. Aminostyrylbenzofuran directly reduces oligomeric amyloid-β and reverses cognitive deficits in Alzheimer transgenic mice. PLoS One. 2014 Apr 23;9(4):e95733. doi: 10.1371/journal.pone.0095733. eCollection 2014. PubMed PMID: 24760018; PubMed Central PMCID: PMC3997483.