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MedKoo Cat#: 591477 | Name: AHN 086

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AHN 086, an irreversible ligand of "peripheral" benzodiazepine receptors.

Chemical Structure

AHN 086
AHN 086
CAS#103625-22-5

Theoretical Analysis

MedKoo Cat#: 591477

Name: AHN 086

CAS#: 103625-22-5

Chemical Formula: C18H14Cl3N3OS

Exact Mass: 424.9923

Molecular Weight: 426.74

Elemental Analysis: C, 50.66; H, 3.31; Cl, 24.92; N, 9.85; O, 3.75; S, 7.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AHN 086; AHN-086; AHN086
IUPAC/Chemical Name
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-(2-isothiocyanatoethyl)-, monohydrochloride
InChi Key
ITUTZPYBBPRLKR-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H13Cl2N3OS.ClH/c19-13-3-1-12(2-4-13)18-15-9-14(20)5-6-16(15)23(8-7-21-11-25)17(24)10-22-18;/h1-6,9H,7-8,10H2;1H
SMILES Code
O=C1N(CCN=C=S)C2=CC=C(Cl)C=C2C(C3=CC=C(Cl)C=C3)=NC1.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 426.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Camins A, Escubedo E, Camarasa J, Carretero J, Newman AH, Kammüller ME. Dog neutrophil stimulation and cell surface expression of heat shock proteins induced by AHN 086. J Pharmacol Exp Ther. 1995 Jul;274(1):242-8. PubMed PMID: 7616404. 2: Gimeno M, Pallás M, Newman AH, Camarasa J, Escubedo E. The role of cyclic nucleotides in the action of peripheral-type benzodiazepine receptor ligands in rat aorta. Gen Pharmacol. 1994 Dec;25(8):1553-61. PubMed PMID: 7721028. 3: Weizman R, Gavish M. Molecular cellular and behavioral aspects of peripheral-type benzodiazepine receptors. Clin Neuropharmacol. 1993 Oct;16(5):401-17. Review. PubMed PMID: 8221702. 4: McEnery MW, Snowman AM, Trifiletti RR, Snyder SH. Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3170-4. PubMed PMID: 1373486; PubMed Central PMCID: PMC48827. 5: Moreno-Sánchez R, Hogue BA, Bravo C, Newman AH, Basile AS, Chiang PK. Inhibition of substrate oxidation in mitochondria by the peripheral-type benzodiazepine receptor ligand AHN 086. Biochem Pharmacol. 1991 May 15;41(10):1479-84. PubMed PMID: 1850277. 6: Moreno-Sánchez R, Bravo C, Gutiérrez J, Newman AH, Chiang PK. Release of Ca2+ from heart and kidney mitochondria by peripheral-type benzodiazepine receptor ligands. Int J Biochem. 1991;23(2):207-13. PubMed PMID: 1847885. 7: McCabe RT, Schoenheimer JA, Skolnick P, Newman AH, Rice KC, Reig JA, Klein DC. [3H]AHN 086 acylates peripheral benzodiazepine receptors in the rat pineal gland. FEBS Lett. 1989 Feb 27;244(2):263-7. PubMed PMID: 2537753. 8: Bolger GT, Newman AH, Rice KC, Lueddens HW, Basile AS, Skolnick P. Characterization of the effects of AHN 086, an irreversible ligand of "peripheral" benzodiazepine receptors, on contraction in guinea-pig atrial and ileal longitudinal smooth muscle. Can J Physiol Pharmacol. 1989 Feb;67(2):126-34. PubMed PMID: 2469529. 9: Newman AH, McCabe RT, Schoenheimer JA, Skolnick P, Rice KC, Reig JA, Klein DC. [3H]AHN 086 acylates peripheral benzodiazepine receptors in the rat pineal gland. NIDA Res Monogr. 1989;95:285-6. PubMed PMID: 2561833. 10: Newman AH, Lueddens HW, Skolnick P, Rice KC. Novel irreversible ligands specific for "peripheral" type benzodiazepine receptors: (+/-)-, (+)-, and (-)-1-(2-chlorophenyl)-N-(1-methylpropyl)-N- (2-isothiocyanatoethyl)-3-isoquinolinecarboxamide and 1-(2-isothiocyanatoethyl)-7-chloro-1,3-dihydro-5-(4-chlorophenyl )-2H-1,4-benzodiazepin-2-one. J Med Chem. 1987 Oct;30(10):1901-5. PubMed PMID: 2821259. 11: Newman AH, Lueddens HW, Skolnick P, Rice KC. Synthesis and biochemical characterization of two novel irreversible ligands specific for "peripheral" benzodiazepine receptors. NIDA Res Monogr. 1987;76:356-62. PubMed PMID: 2830529. 12: Lueddens HW, Newman AH, Rice KC, Skolnick P. AHN 086: an irreversible ligand of "peripheral" benzodiazepine receptors. Mol Pharmacol. 1986 Jun;29(6):540-5. PubMed PMID: 3012318.