MW108 | CAS#1454658-89-9 | p38αMAPK inhibitor

MedKoo Cat#: 562995 | Name: MW108

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MW108 is an active site targeted, CNS-active, p38αMAPK inhibitor. It acts by ameliorating beta-amyloid induced synaptic and cognitive dysfunction and preventing early memory loss in Alzheimer's disease.

Chemical Structure

MW108

CAS#1454658-89-9

Theoretical Analysis

MedKoo Cat#: 562995

Name: MW108

CAS#: 1454658-89-9

Chemical Formula: C21H19ClN4

Exact Mass:

Molecular Weight: 362.86

Elemental Analysis: C, 69.51; H, 5.28; Cl, 9.77; N, 15.44

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

MW108; MW-108; MW 108; MW01-11-108; MW01 11 108; MW0111108;

IUPAC/Chemical Name

N,N-dimethyl-6-(naphthalen-2-yl)-5-(pyridin-4-yl)pyridazin-3-amine hydrochloride

InChi Key

YCTPOOSUMJYWMU-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H18N4.ClH/c1-25(2)20-14-19(16-9-11-22-12-10-16)21(24-23-20)18-8-7-15-5-3-4-6-17(15)13-18;/h3-14H,1-2H3;1H

SMILES Code

CN(C)C1=NN=C(C2=CC(C=CC=C3)=C3C=C2)C(C4=CC=NC=C4)=C1.Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 362.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kheiri G, Dolatshahi M, Rahmani F, Rezaei N. Role of p38/MAPKs in Alzheimer's disease: implications for amyloid beta toxicity targeted therapy. Rev Neurosci. 2018 May 28. pii: /j/revneuro.ahead-of-print/revneuro-2018-0008/revneuro-2018-0008.xml. doi: 10.1515/revneuro-2018-0008. [Epub ahead of print] PubMed PMID: 29804103. 2: Watterson DM, Grum-Tokars VL, Roy SM, Schavocky JP, Bradaric BD, Bachstetter AD, Xing B, Dimayuga E, Saeed F, Zhang H, Staniszewski A, Pelletier JC, Minasov G, Anderson WF, Arancio O, Van Eldik LJ. Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction. PLoS One. 2013 Jun 26;8(6):e66226. doi: 10.1371/journal.pone.0066226. Print 2013. PubMed PMID: 23840427; PubMed Central PMCID: PMC3694096.