Synonym
Anacardone; Anacordone; Astrocar; beta-Pyrimidum;
IUPAC/Chemical Name
3-Pyridinecarboxamide, N,N-diethyl-
InChi Key
NCYVXEGFNDZQCU-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H14N2O/c1-3-12(4-2)10(13)9-6-5-7-11-8-9/h5-8H,3-4H2,1-2H3
SMILES Code
O=C(C1=CC=CN=C1)N(CC)CC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Nikethamide, one of the respiratory central stimulants, has the potential for respiratory failure research.
In vitro activity:
To investigate the effects of nikethamide on the generation and modulation of rhythmic respiration of neonatal rats and the role of 5-HT(2A) receptor in this course, experiments were performed on the transverse medullary slices of neonatal rats (both sexes, 1-3 d) in vitro. Nikethamide increased RRDA in transverse medullary slices at 0.5-7 μg/mL, and 5 μg/mL was the most effective concentration.
Reference: Sheng Li Xue Bao. 2008 Apr 25;60(2):216-20. https://pubmed.ncbi.nlm.nih.gov/18425309/
|
Solvent |
mg/mL |
mM |
comments |
| Solubility |
| DMSO |
18.0 |
100.99 |
|
| Water |
50.0 |
280.53 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
178.24
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
Qian ZB, Wu ZH. [Role of 5-HT(2A) receptor in increase in respiratory-related rhythmic discharge activity by nikethamide in neonatal rat transverse medullary slices]. Sheng Li Xue Bao. 2008 Apr 25;60(2):216-20. Chinese. PMID: 18425309.
In vitro protocol:
Qian ZB, Wu ZH. [Role of 5-HT(2A) receptor in increase in respiratory-related rhythmic discharge activity by nikethamide in neonatal rat transverse medullary slices]. Sheng Li Xue Bao. 2008 Apr 25;60(2):216-20. Chinese. PMID: 18425309.
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