Chlorasquin | CAS#18921-73-8 | dihydrofolate reductase inhibitor

MedKoo Cat#: 596911 | Name: Chlorasquin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chlorasquin is an inhibitor of dihydrofolate reductase.

Chemical Structure

Chlorasquin

CAS#18921-73-8

Theoretical Analysis

MedKoo Cat#: 596911

Name: Chlorasquin

CAS#: 18921-73-8

Chemical Formula: C20H19ClN6O5

Exact Mass: 458.1105

Molecular Weight: 458.85

Elemental Analysis: C, 52.35; H, 4.17; Cl, 7.73; N, 18.32; O, 17.43

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Chlorasquin; Ccnsc 529,861; Ccnsc-529,861; Ccnsc529,861; SK 29861; SK-29861; SK29861; NSC 529861; NSC-529861; NSC529861;

IUPAC/Chemical Name

(4-(((2,4-diamino-5-chloroquinazolin-6-yl)methyl)amino)benzoyl)-L-aspartic acid

InChi Key

GWIBVUFMBFNYLT-ZDUSSCGKSA-N

InChi Code

InChI=1S/C20H19ClN6O5/c21-16-10(3-6-12-15(16)17(22)27-20(23)26-12)8-24-11-4-1-9(2-5-11)18(30)25-13(19(31)32)7-14(28)29/h1-6,13,24H,7-8H2,(H,25,30)(H,28,29)(H,31,32)(H4,22,23,26,27)/t13-/m0/s1

SMILES Code

O=C(O)C[C@@H](C(O)=O)NC(C1=CC=C(NCC2=C(Cl)C3=C(N)N=C(N)N=C3C=C2)C=C1)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 458.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Hynes JB, Eason DE, Garrett CM, Colvin PL Jr. Quinazolines as inhibitors of dihydrofolate reductase. 4. Classical analogues of folic and isofolic acids. J Med Chem. 1977 Apr;20(4):588-91. PubMed PMID: 850245. 2: Chello PL, McQueen CA, DeAngelis LM, Bertino JR. Elevation of dihydrofolate reductase, thymidylate synthetase, and thymidine kinase in cultured mammalian cells after exposure to folate antagonists. Cancer Res. 1976 Jul;36(7 PT 1):2442-9. PubMed PMID: 1277151.