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MedKoo Cat#: 596900 | Name: Angiotensin amide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Angiotensin amide is the octapeptide amide of bovine angiotensin II used to increase blood pressure by vasoconstriction.

Chemical Structure

Angiotensin amide
Angiotensin amide
CAS#53-73-6

Theoretical Analysis

MedKoo Cat#: 596900

Name: Angiotensin amide

CAS#: 53-73-6

Chemical Formula: C49H70N14O11

Exact Mass: 1030.5348

Molecular Weight: 1031.18

Elemental Analysis: C, 57.07; H, 6.84; N, 19.02; O, 17.07

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Angiotensin amide; Angiotensin; Angiotensinamide; Hypertensine; NSC 107678; NSC-107678; NSC107678;
IUPAC/Chemical Name
L-asparaginyl-L-arginyl-L-valyl-L-tyrosyl-L-valyl-L-histidyl-L-prolyl-L-phenylalanine
InChi Key
JYPVVOOBQVVUQV-CGHBYZBKSA-N
InChi Code
1S/C49H70N14O11/c1-26(2)39(61-42(67)33(12-8-18-55-49(52)53)57-41(66)32(50)23-38(51)65)45(70)58-34(20-29-14-16-31(64)17-15-29)43(68)62-40(27(3)4)46(71)59-35(22-30-24-54-25-56-30)47(72)63-19-9-13-37(63)44(69)60-36(48(73)74)21-28-10-6-5-7-11-28/h5-7,10-11,14-17,24-27,32-37,39-40,64H,8-9,12-13,18-23,50H2,1-4H3,(H2,51,65)(H,54,56)(H,57,66)(H,58,70)(H,59,71)(H,60,69)(H,61,67)(H,62,68)(H,73,74)(H4,52,53,55)/t32-,33-,34-,35-,36-,37-,39-,40-/m0/s1
SMILES Code
CC([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(O)=O)Cc2ccccc2)=O)=O)Cc3nc[nH]c3)=O)C(C)C)=O)Cc4ccc(O)cc4)=O)NC([C@@H](NC([C@H](CC(N)=O)N)=O)CCCNC(N)=N)=O)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,031.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lee HW, Lim HJ, Jun JH, Choi J, Lee MS. Ginseng for Treating Hypertension: A Systematic Review and Meta-Analysis of Double Blind, Randomized, Placebo-Controlled Trials. Curr Vasc Pharmacol. 2017;15(6):549-556. doi: 10.2174/1570161115666170713092701. Review. PubMed PMID: 28707603. 2: Staniszewska-Slezak E, Wiercigroch E, Fedorowicz A, Buczek E, Mateuszuk L, Baranska M, Chlopicki S, Malek K. A possible Fourier transform infrared-based plasma fingerprint of angiotensin-converting enzyme inhibitor-induced reversal of endothelial dysfunction in diabetic mice. J Biophotonics. 2018 Feb;11(2). doi: 10.1002/jbio.201700044. Epub 2017 Jul 31. PubMed PMID: 28700133. 3: Perazzo J, Lima C, Heras M, Bardají E, Lopes-Ferreira M, Castanho M. Neuropeptide Kyotorphin Impacts on Lipopolysaccharide-Induced Glucocorticoid-Mediated Inflammatory Response. A Molecular Link to Nociception, Neuroprotection, and Anti-Inflammatory Action. ACS Chem Neurosci. 2017 Aug 16;8(8):1663-1667. doi: 10.1021/acschemneuro.7b00007. Epub 2017 May 9. PubMed PMID: 28472878. 4: Bubb KJ, Kok C, Tang O, Rasko NB, Birgisdottir AB, Hansen T, Ritchie R, Bhindi R, Reisman SA, Meyer C, Ward K, Karimi Galougahi K, Figtree GA. The NRF2 activator DH404 attenuates adverse ventricular remodeling post-myocardial infarction by modifying redox signalling. Free Radic Biol Med. 2017 Jul;108:585-594. doi: 10.1016/j.freeradbiomed.2017.04.027. Epub 2017 Apr 21. PubMed PMID: 28438659. 5: Wiencek JR, Colby JM, Nichols JH. Rapid Assessment of Drugs of Abuse. Adv Clin Chem. 2017;80:193-225. doi: 10.1016/bs.acc.2016.11.003. Epub 2016 Dec 28. PubMed PMID: 28431640. 6: Jiao T, Yao Y, Zhang B, Hao DC, Sun QF, Li JB, Yuan C, Jing B, Wang YP, Wang HY. Role of MicroRNA-103a Targeting ADAM10 in Abdominal Aortic Aneurysm. Biomed Res Int. 2017;2017:9645874. doi: 10.1155/2017/9645874. Epub 2017 Mar 5. PubMed PMID: 28357407; PubMed Central PMCID: PMC5357520. 7: Karpińska O, Baranowska-Kuczko M, Kloza M, Ambroz Ewicz E, Kozłowski T, Kasacka I, Malinowska B, Kozłowska H. Activation of CB(1) receptors by 2-arachidonoylglycerol attenuates vasoconstriction induced by U46619 and angiotensin II in human and rat pulmonary arteries. Am J Physiol Regul Integr Comp Physiol. 2017 Jun 1;312(6):R883-R893. doi: 10.1152/ajpregu.00324.2016. Epub 2017 Mar 29. PubMed PMID: 28356298. 8: Kim M, Kim M, Yoo HJ, Jang HY, Lee SH, Lee JH. Effects of overweight and the PLA2G7 V279F polymorphism on the association of age with systolic blood pressure. PLoS One. 2017 Mar 23;12(3):e0173611. doi: 10.1371/journal.pone.0173611. eCollection 2017. PubMed PMID: 28334001; PubMed Central PMCID: PMC5363925. 9: Ohmori KH, Ooya T, Takeuchi T. Crosslinked Network with Rotatable Binding Sites Based on Monocarboxylated α-Cyclodextrin [2]Rotaxane Capable of Angiotensin III Recognition. Chemistry. 2017 Apr 3;23(19):4708-4712. doi: 10.1002/chem.201700206. Epub 2017 Mar 16. PubMed PMID: 28185437. 10: Lengyel I, Toth F, Biyashev D, Szatmari I, Monory K, Tomboly C, Toth G, Benyhe S, Borsodi A. A novel non-opioid binding site for endomorphin-1. J Physiol Pharmacol. 2016 Aug;67(4):605-616. PubMed PMID: 27779481. 11: Bouabdallah S, Ben Dhia MT, Driss MR, Touil S. Investigation of the energy barrier to the rotation of amide CN bonds in ACE inhibitors by NMR, dynamic HPLC and DFT. J Pharm Biomed Anal. 2016 Sep 5;128:416-425. doi: 10.1016/j.jpba.2016.05.049. Epub 2016 Jun 1. PubMed PMID: 27344631. 12: Kanazawa I, Sugimoto T. [Bone and calcium metabolism in life-style related diseases]. Clin Calcium. 2016 Mar;26(3):399-404. doi: CliCa1603399404. Review. Japanese. PubMed PMID: 26923977. 13: Khammy MM, Angus JA, Wright CE. Vascular reactivity of rabbit isolated renal and femoral resistance arteries in renal wrap hypertension. Eur J Pharmacol. 2016 Feb 15;773:32-41. doi: 10.1016/j.ejphar.2016.01.004. Epub 2016 Jan 22. PubMed PMID: 26806799. 14: Liang JW, Zhang W, Sarlin J, Boniece I. Case of Cerebral Amyloid Angiopathy-Related Inflammation - Is the Absence of Cerebral Microbleeds A Good Prognostic Sign? J Stroke Cerebrovasc Dis. 2015 Nov;24(11):e319-22. doi: 10.1016/j.jstrokecerebrovasdis.2015.08.001. Epub 2015 Sep 2. PubMed PMID: 26341733. 15: Shi X, O'Neill MM, MacDonnell S, Brookes PS, Yan C, Berk BC. The RSK Inhibitor BIX02565 Limits Cardiac Ischemia/Reperfusion Injury. J Cardiovasc Pharmacol Ther. 2016 Mar;21(2):177-86. doi: 10.1177/1074248415591700. Epub 2015 Jun 30. PubMed PMID: 26130615; PubMed Central PMCID: PMC4822162. 16: Fatani T, Binjab A, Weiler H, Sharma A, Rodd C. Persistent elevation of fibroblast growth factor 23 concentrations in healthy appropriate-for-gestational-age preterm infants. J Pediatr Endocrinol Metab. 2015 Jul;28(7-8):825-32. doi: 10.1515/jpem-2014-0186. PubMed PMID: 25968436. 17: Blann AD, Lip GY. Renal, endothelial function, warfarin management, and the CHADS2, CHA2DS2VASc and HAS-BLED scores inpredicting MACE in AF. Thromb Haemost. 2015 May;113(5):1155-7. doi: 10.1160/TH14-11-0932. Epub 2015 Feb 26. PubMed PMID: 25716989. 18: Wright JW, Harding JW. The Brain Hepatocyte Growth Factor/c-Met Receptor System: A New Target for the Treatment of Alzheimer's Disease. J Alzheimers Dis. 2015;45(4):985-1000. doi: 10.3233/JAD-142814. Review. PubMed PMID: 25649658. 19: Wang SJ, Laulederkind SJ, Hayman GT, Petri V, Liu W, Smith JR, Nigam R, Dwinell MR, Shimoyama M. PhenoMiner: a quantitative phenotype database for the laboratory rat, Rattus norvegicus. Application in hypertension and renal disease. Database (Oxford). 2015 Jan 28;2015. pii: bau128. doi: 10.1093/database/bau128. Print 2015. PubMed PMID: 25632109; PubMed Central PMCID: PMC4309021. 20: Brosnihan KB, Pulgar VM, Gallagher PE, Neves LA, Yamaleyeva LM. Local uterine Ang-(1-7) infusion augments the expression of cannabinoid receptors and differentially alters endocannabinoid metabolizing enzymes in the decidualized uterus of pseudopregnant rats. Reprod Biol Endocrinol. 2015 Jan 17;13:5. doi: 10.1186/1477-7827-13-5. PubMed PMID: 25596750; PubMed Central PMCID: PMC4325957.

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