Synonym
Scorbamic acid; L-Scorbamic acid; Scorbaminic; Amino reductone;
IUPAC/Chemical Name
(S)-3-amino-5-((R)-1,2-dihydroxyethyl)-4-hydroxyfuran-2(5H)-one
InChi Key
RTPBEMVDAXPYRC-MVHIGOERSA-N
InChi Code
InChI=1S/C6H9NO5/c7-3-4(10)5(2(9)1-8)12-6(3)11/h2,5,8-10H,1,7H2/t2-,5+/m1/s1
SMILES Code
O=C1O[C@@H]([C@H](O)CO)C(O)=C1N
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
175.14
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Trang VT, Takeuchi H, Kudo H, Aoki A, Katsuno S, Shimamura T, Sugiura T, Ukeda H. Antimicrobial activity of aminoreductone against Helicobacter pylori. J Agric Food Chem. 2009 Dec 9;57(23):11343-8. doi: 10.1021/jf9026876. PubMed PMID: 19891477.
2: Dittrich R, El-Massry F, Kunz K, Rinaldi F, Peich CC, Beckmann MW, Pischetsrieder M. Maillard reaction products inhibit oxidation of human low-density lipoproteins in vitro. J Agric Food Chem. 2003 Jun 18;51(13):3900-4. PubMed PMID: 12797763.
3: Kurata T, Otsuka Y. Amino-reductones. Formation mechanisms and structural characteristics. Adv Exp Med Biol. 1998;434:269-76. PubMed PMID: 9598206.
4: Wimalasena K, Wimalasena DS. The reduction of membrane-bound dopamine beta-monooxygenase in resealed chromaffin granule ghosts. Is intragranular ascorbic acid a mediator for extragranular reducing equivalents? J Biol Chem. 1995 Nov 17;270(46):27516-24. PubMed PMID: 7499210.
5: Wimalasena K, Dharmasena S. Continuous spectrophotometric assay for ascorbate oxidase based on a novel chromophoric substrate, 2-aminoascorbic acid. Anal Biochem. 1993 Apr;210(1):58-62. PubMed PMID: 8489025.
6: Wimalasena K, Wimalasena DS. Continuous spectrophotometric assays for dopamine beta-monooxygenase based on two novel electron donors: N,N-dimethyl-1,4-phenylenediamine and 2-aminoascorbic acid. Anal Biochem. 1991 Sep 2;197(2):353-61. PubMed PMID: 1785690.
7: AMBROSE AM, ROBBINS DJ, DEEDS F. Acute and subacute toxicity of amino-hexose-reductones. Proc Soc Exp Biol Med. 1961 Mar;106:656-9. PubMed PMID: 13682918.
