Men 10208 | CAS#129781-07-3 | neurokinin A receptor antagonist

MedKoo Cat#: 596884 | Name: Men 10208

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Men 10208 is a neurokinin A receptor antagonist.

Chemical Structure

Men 10208

CAS#129781-07-3

Theoretical Analysis

MedKoo Cat#: 596884

Name: Men 10208

CAS#: 129781-07-3

Chemical Formula: C61H75N15O12

Exact Mass: 1209.5720

Molecular Weight: 1210.36

Elemental Analysis: C, 60.53; H, 6.25; N, 17.36; O, 15.86

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

Men 10208; Men-10208; Men10208; Thr-asp-tyr-trp-val-trp-trp-arg-NH2;

IUPAC/Chemical Name

(6S,9R,12R,15S,18R,21S,24S)-9,12,18-tris((1H-indol-3-yl)methyl)-1-amino-24-((2S,3R)-2-amino-3-hydroxybutanamido)-6-carbamoyl-21-(4-hydroxybenzyl)-1-imino-15-isopropyl-8,11,14,17,20,23-hexaoxo-2,7,10,13,16,19,22-heptaazahexacosan-26-oic acid

InChi Key

FDMDWRMJOFJCPP-AVMQDAPYSA-N

InChi Code

InChI=1S/C61H75N15O12/c1-31(2)52(76-58(86)48(26-36-30-69-43-16-9-6-13-40(36)43)73-54(82)45(23-33-18-20-37(78)21-19-33)71-57(85)49(27-50(79)80)74-59(87)51(62)32(3)77)60(88)75-47(25-35-29-68-42-15-8-5-12-39(35)42)56(84)72-46(24-34-28-67-41-14-7-4-11-38(34)41)55(83)70-44(53(63)81)17-10-22-66-61(64)65/h4-9,11-16,18-21,28-32,44-49,51-52,67-69,77-78H,10,17,22-27,62H2,1-3H3,(H2,63,81)(H,70,83)(H,71,85)(H,72,84)(H,73,82)(H,74,87)(H,75,88)(H,76,86)(H,79,80)(H4,64,65,66)/t32-,44+,45+,46-,47-,48-,49+,51+,52+/m1/s1

SMILES Code

N=C(N)NCCC[C@@H](C(N)=O)NC([C@@H](CC1=CNC2=C1C=CC=C2)NC([C@@H](CC3=CNC4=C3C=CC=C4)NC([C@H](C(C)C)NC([C@@H](CC5=CNC6=C5C=CC=C6)NC([C@H](CC7=CC=C(O)C=C7)NC([C@H](CC(O)=O)NC([C@H]([C@H](O)C)N)=O)=O)=O)=O)=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,210.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Medeiros MD, Turner AJ. Metabolic stability of some tachykinin analogues to cell-surface peptidases: roles for endopeptidase-24.11 and aminopeptidase N. Peptides. 1995;16(3):441-7. PubMed PMID: 7651897. 2: Patacchini R, Maggi CA. Amastatin interferes with the antagonist properties of MEN 10,208 in the rabbit pulmonary artery but not in the hamster trachea. Eur J Pharmacol. 1993 May 12;236(1):31-7. PubMed PMID: 8391454. 3: Henderson AK, Yamamura HI, Maggi CA, Buck SH, Van Giersbergen PL, Roeske WR. Demonstration of a neurokinin A receptor subtype in transfected fibroblasts. Eur J Pharmacol. 1992 Feb 13;225(2):175-8. PubMed PMID: 1312943. 4: Rovero P, Quartara L, Fabbri G. Solid-phase synthesis of neurokinin A antagonists. Comparison of the Boc and Fmoc methods. Int J Pept Protein Res. 1991 Feb;37(2):140-4. PubMed PMID: 1850390.