Prumycin dihydrochloride | CAS#57420-47-0 | Antifungal antibiotic

MedKoo Cat#: 596863 | Name: Prumycin dihydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Prumycin dihydrochloride is an antifungal antibiotic.

Chemical Structure

Prumycin dihydrochloride

CAS#57420-47-0

Theoretical Analysis

MedKoo Cat#: 596863

Name: Prumycin dihydrochloride

CAS#: 57420-47-0

Chemical Formula: C8H19Cl2N3O4

Exact Mass:

Molecular Weight: 292.15

Elemental Analysis: C, 32.89; H, 6.56; Cl, 24.27; N, 14.38; O, 21.90

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Prumycin dihydrochloride; Prumycin HCl;

IUPAC/Chemical Name

(R)-2-amino-N-((2S,3R,4R)-4-amino-1,3-dihydroxy-5-oxopentan-2-yl)propanamide dihydrochloride

InChi Key

PKVUUDMKVLKVNA-CYBHTWLKSA-N

InChi Code

InChI=1S/C8H17N3O4.2ClH/c1-4(9)8(15)11-6(3-13)7(14)5(10)2-12;;/h2,4-7,13-14H,3,9-10H2,1H3,(H,11,15);2*1H/t4-,5+,6+,7-;;/m1../s1

SMILES Code

O=C[C@H](N)[C@H]([C@@H](NC([C@H](N)C)=O)CO)O.[H]Cl.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 292.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Tanaka K, Fukuda M, Amaki Y, Sakaguchi T, Inai K, Ishihara A, Nakajima H. Importance of prumycin produced by Bacillus amyloliquefaciens SD-32 in biocontrol against cucumber powdery mildew disease. Pest Manag Sci. 2017 Dec;73(12):2419-2428. doi: 10.1002/ps.4630. Epub 2017 Aug 29. PubMed PMID: 28560847. 2: Kumari M, Chandra S, Tiwari N, Subbarao N. High Throughput Virtual Screening to Identify Novel natural product Inhibitors for MethionyltRNA-Synthetase of Brucella melitensis. Bioinformation. 2017 Jan 20;13(1):8-16. doi: 10.6026/97320630013008. eCollection 2017. PubMed PMID: 28479744; PubMed Central PMCID: PMC5405087. 3: Otoguro K, Ishiyama A, Kobayashi M, Sekiguchi H, Izuhara T, Sunazuka T, Tomoda H, Yamada H, Omura S. In vitro and in vivo antimalarial activities of a carbohydrate antibiotic, prumycin, against drug-resistant strains of Plasmodia. J Antibiot (Tokyo). 2004 Jun;57(6):400-2. PubMed PMID: 15323130. 4: Hamada M, Ikeda T, Manabe M, Gomi S, Kondo S, Takeuchi T, Umezawa H. Prumycin produced by Bacillus cereus. J Antibiot (Tokyo). 1983 Jan;36(1):86. PubMed PMID: 6432762. 5: Okubo S, Morimoto M, Mineura K, Marumo H, Omura S. Studies on antitumor activity of prumycin. IV. Effect of prumycin on mouse immune system. J Antibiot (Tokyo). 1980 Feb;33(2):231-5. PubMed PMID: 7380733. 6: Okubo S, Nakamura N, Morimoto M, Mineura K, Marumo H, Omura S. Studies on antitumor activity of prumycin. II. Studies on distribution and excretion of prumycin. J Antibiot (Tokyo). 1980 Feb;33(2):221-5. PubMed PMID: 7380732. 7: Okubo S, Nakamura N, Morimoto M, Mineura K, Marumo H, Omura S. Studies on antitumor activity of prumycin. III. Mode of action of prumycin on HeLa S-3 cells. J Antibiot (Tokyo). 1980 Feb;33(2):226-30. PubMed PMID: 6155368. 8: Okubo S, Nakamura N, Ito K, Marumo H, Tanaka M, Omura S. Antitumor activity of prumycin. J Antibiot (Tokyo). 1979 Apr;32(4):347-54. PubMed PMID: 468722. 9: Hasegawa A, Aritake N, Kiso M. Synthesis of prumycin and related compounds. Carbohydr Res. 1976 Dec;52:137-49. PubMed PMID: 1016984. 10: Hasegawa A, Aritake N, Kiso M. A new synthesis of prumycin. Carbohydr Res. 1976 Oct;51(1):C10-C12. PubMed PMID: 1000523. 11: Schwartz JL, Katagiri M, Omura S, Tishler M. The mechanism of prumycin action. J Antibiot (Tokyo). 1974 Jun;27(6):379-85. PubMed PMID: 4854949. 12: Omura S, Katagiri M, Atsumi K, Hata T, Jakubowski AA, Springs EB, Tishler M. Structure of prumycin. J Chem Soc Perkin 1. 1974;0(14):1627-31. PubMed PMID: 4472323. 13: Hata T, Omura S, Katagiri M, Atsumi K, Awaya J. A new antifungal antibiotic, prumycin. J Antibiot (Tokyo). 1971 Dec;24(12):900-1. PubMed PMID: 5140535.