MedKoo Cat#: 562975 | Name: 0990CL
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

0990CL is an inhibitor of heterotrimeric Gαi subunits. 0990CL showed direct interaction with Gαi. Several compounds showed Gαi specific inhibition and were able to block α2AR mediated regulation of cAMP.

Chemical Structure

0990CL
0990CL
CAS#511514-03-7

Theoretical Analysis

MedKoo Cat#: 562975

Name: 0990CL

CAS#: 511514-03-7

Chemical Formula: C21H21N5

Exact Mass: 343.1797

Molecular Weight: 343.43

Elemental Analysis: C, 73.44; H, 6.16; N, 20.39

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 weeks
10Special USD 750.00 2 weeks
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Related CAS #
No Data
Synonym
0990CL; 0990-CL; 0990 CL;
IUPAC/Chemical Name
(4-Phenyl-quinazolin-2-yl)-(4,6,6-trimethyl-1,6-dihydro-pyrimidin-2-yl)-amine
InChi Key
DXICUHJLOMNKOU-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H21N5/c1-14-13-21(2,3)26-20(22-14)25-19-23-17-12-8-7-11-16(17)18(24-19)15-9-5-4-6-10-15/h4-13H,1-3H3,(H2,22,23,24,25,26)
SMILES Code
CC1(C)C=C(C)N=C(NC2=NC(C3=CC=CC=C3)=C4C=CC=CC4=N2)N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
0990CL is a specific heterotrimeric Gαi subunit inhibitor by direct interaction with Gαi.
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM
Solubility
DMSO 50.0 145.59
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 343.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
Appleton KM, Bigham KJ, Lindsey CC, Hazard S, Lirjoni J, Parnham S, Hennig M, Peterson YK. Development of inhibitors of heterotrimeric Gαi subunits. Bioorg Med Chem. 2014 Jul 1;22(13):3423-34. doi: 10.1016/j.bmc.2014.04.035. Epub 2014 Apr 26. PMID: 24818958; PMCID: PMC4103618.