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MedKoo Cat#: 562973 | Name: SJ3366

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SJ3366 is a unique and highly potent nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 (HIV-1) and HIV-2.

Chemical Structure

SJ3366
SJ3366
CAS#195720-26-4

Theoretical Analysis

MedKoo Cat#: 562973

Name: SJ3366

CAS#: 195720-26-4

Chemical Formula: C21H24N2O3

Exact Mass: 352.1787

Molecular Weight: 352.43

Elemental Analysis: C, 71.57; H, 6.86; N, 7.95; O, 13.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SJ3366; SJ-3366; SJ 3366;
IUPAC/Chemical Name
1-(Cyclopent-3-en-1-ylmethyl)-6-(3,5-dimethylbenzoyl)-5-ethylpyrimidine-2,4-dione
InChi Key
BEMROAADXJFLBI-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H24N2O3/c1-4-17-18(19(24)16-10-13(2)9-14(3)11-16)23(21(26)22-20(17)25)12-15-7-5-6-8-15/h5-6,9-11,15H,4,7-8,12H2,1-3H3,(H,22,25,26)
SMILES Code
O=C1NC(C(CC)=C(C(C2=CC(C)=CC(C)=C2)=O)N1CC3CC=CC3)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 352.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wamberg M, Pedersen EB, El-Brollosy NR, Nielsen C. Synthesis of 6-arylvinyl analogues of the HIV drugs SJ-3366 and Emivirine. Bioorg Med Chem. 2004 Mar 1;12(5):1141-9. PubMed PMID: 14980626. 2: Baba M. SJ-3366 Sam Jin Pharmaceutical. Curr Opin Investig Drugs. 2002 Aug;3(8):1146-8. Review. PubMed PMID: 12211405. 3: Buckheit RW Jr, Watson K, Fliakas-Boltz V, Russell J, Loftus TL, Osterling MC, Turpin JA, Pallansch LA, White EL, Lee JW, Lee SH, Oh JW, Kwon HS, Chung SG, Cho EH. SJ-3366, a unique and highly potent nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 (HIV-1) that also inhibits HIV-2. Antimicrob Agents Chemother. 2001 Feb;45(2):393-400. PubMed PMID: 11158731; PubMed Central PMCID: PMC90303.