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MedKoo Cat#: 596833 | Name: Snf 8702

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Snf 8702 is a selective radioligand for CCKB receptors.

Chemical Structure

Snf 8702
Snf 8702
CAS#129228-52-0

Theoretical Analysis

MedKoo Cat#: 596833

Name: Snf 8702

CAS#: 129228-52-0

Chemical Formula: C53H70N10O13

Exact Mass: 1054.5124

Molecular Weight: 1055.20

Elemental Analysis: C, 60.33; H, 6.69; N, 13.27; O, 19.71

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Snf 8702; Snf-8702; Snf8702;
IUPAC/Chemical Name
(3S,6S,9S,15S,18S,21S)-9-((1H-indol-3-yl)methyl)-21-amino-3-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-6,15-dibutyl-18-(4-hydroxybenzyl)-7,16-dimethyl-5,8,11,14,17,20-hexaoxo-4,7,10,13,16,19-hexaazatricosanedioic acid
InChi Key
JUKSSJWDVMBURS-TZLMNZOISA-N
InChi Code
InChI=1S/C53H70N10O13/c1-5-7-18-42(62(3)52(75)40(25-32-20-22-34(64)23-21-32)61-48(71)36(54)27-45(66)67)50(73)57-30-44(65)58-41(26-33-29-56-37-17-13-12-16-35(33)37)53(76)63(4)43(19-8-6-2)51(74)60-39(28-46(68)69)49(72)59-38(47(55)70)24-31-14-10-9-11-15-31/h9-17,20-23,29,36,38-43,56,64H,5-8,18-19,24-28,30,54H2,1-4H3,(H2,55,70)(H,57,73)(H,58,65)(H,59,72)(H,60,74)(H,61,71)(H,66,67)(H,68,69)/t36-,38-,39-,40-,41-,42-,43-/m0/s1
SMILES Code
O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CC(O)=O)NC([C@H](CCCC)N(C([C@H](CC2=CNC3=C2C=CC=C3)NC(CNC([C@H](CCCC)N(C([C@H](CC4=CC=C(O)C=C4)NC([C@H](CC(O)=O)N)=O)=O)C)=O)=O)=O)C)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,055.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gronier B, Debonnel G. CCKB receptors mediate CCK-8S-induced activation of dorsal hippocampus CA3 pyramidal neurons: an in vivo electrophysiological study in the rat. Synapse. 1995 Oct;21(2):158-68. PubMed PMID: 8584977. 2: Malatynska E, Knapp RJ, Stropova D, Varga E, Yamamura HI. The role of the Val353 residue in antagonist binding to rat CCK-B receptors. Neuroreport. 1995 Jun 19;6(9):1325-9. PubMed PMID: 7669996. 3: Slaninova J, Knapp RJ, Weber SJ, Davis TP, Fang SN, Hruby VJ, Yamamura HI. [125I]SNF 8702: a selective radioligand for CCKB receptors. Peptides. 1995;16(2):221-4. PubMed PMID: 7784252. 4: Knapp RJ, Malatynska E, Peterson P, Zalewska T, Fang S, Hruby VJ, Smith TL, Yamamura HI. [N-methylnorleucine-(28,31)]cholecystokinin-(26-33) (SNF 8702) activity at a cloned rat CCKB receptor. Eur J Pharmacol. 1994 Oct 14;269(2):133-8. PubMed PMID: 7851490. 5: Knapp RJ, Malatynska E, Hashimoto S, Fang S, Hunt M, Wamsley JK, Peterson P, Zalewska T, Hruby VJ, Yamamura HI. [3H]SNF8702 autoradiography of CCK-B receptors in guinea pig brain and studies with a cloned rat CCK-B receptor. Ann N Y Acad Sci. 1994 Mar 23;713:380-3. PubMed PMID: 8185194. 6: Durieux C, Ruiz-Gayo M, Corringer PJ, Bergeron F, Ducos B, Roques BP. [3H]pBC 264, a suitable probe for studying cholecystokinin-B receptors: binding characteristics in rodent brains and comparison with [3H]SNF 8702. Mol Pharmacol. 1992 Jun;41(6):1089-95. PubMed PMID: 1614411. 7: Ayres EA, Parkhurst DN, Fang S, Kramer TH, Hruby VJ, Burks TF. Antinociceptive and gastrointestinal transit effects of cholecystokinin (CCK-8) and related analogs of CCK-8 in the mouse. Proc West Pharmacol Soc. 1991;34:477-84. PubMed PMID: 1788334. 8: Knapp RJ, Vaughn LK, Fang SN, Bogert CL, Yamamura MS, Hruby VJ, Yamamura HI. A new, highly selective CCK-B receptor radioligand ([3H][N-methyl-Nle28,31]CCK26-33): evidence for CCK-B receptor heterogeneity. J Pharmacol Exp Ther. 1990 Dec;255(3):1278-86. PubMed PMID: 2262906.