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MedKoo Cat#: 596830 | Name: Jmv 170

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Jmv 170 is the C-terminal heptapeptide of cholecystokinin in which the C-terminal pehnylalanine residue has been replaced by a phenylethylamide group; has partial agonist CCK activity on pancreatic amylase release.

Chemical Structure

Jmv 170
Jmv 170
CAS#117829-60-4

Theoretical Analysis

MedKoo Cat#: 596830

Name: Jmv 170

CAS#: 117829-60-4

Chemical Formula: C51H68N8O14S

Exact Mass: 1048.4576

Molecular Weight: 1049.20

Elemental Analysis: C, 58.38; H, 6.53; N, 10.68; O, 21.35; S, 3.06

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Jmv 170; Jmv-170; Jmv170;
IUPAC/Chemical Name
(6S,9S,15S,18S,21S)-15-((1H-indol-3-yl)methyl)-9,18-dibutyl-21-carbamoyl-2,2-dimethyl-4,7,10,13,16,19-hexaoxo-20-phenethyl-6-(4-(sulfooxy)benzyl)-3-oxa-5,8,11,14,17,20-hexaazatricosan-23-oic acid
InChi Key
UPHNCRZPDMOIDF-FDXDWZSASA-N
InChi Code
InChI=1S/C51H68N8O14S/c1-6-8-18-38(56-47(65)40(58-50(68)72-51(3,4)5)27-33-21-23-35(24-22-33)73-74(69,70)71)46(64)54-31-43(60)55-41(28-34-30-53-37-20-14-13-17-36(34)37)48(66)57-39(19-9-7-2)49(67)59(42(45(52)63)29-44(61)62)26-25-32-15-11-10-12-16-32/h10-17,20-24,30,38-42,53H,6-9,18-19,25-29,31H2,1-5H3,(H2,52,63)(H,54,64)(H,55,60)(H,56,65)(H,57,66)(H,58,68)(H,61,62)(H,69,70,71)/t38-,39-,40-,41-,42-/m0/s1
SMILES Code
O=C(O)C[C@@H](C(N)=O)N(C([C@H](CCCC)NC([C@H](CC1=CNC2=C1C=CC=C2)NC(CNC([C@H](CCCC)NC([C@H](CC3=CC=C(OS(=O)(O)=O)C=C3)NC(OC(C)(C)C)=O)=O)=O)=O)=O)=O)CCC4=CC=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,049.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nagain C, Lignon MF, Galas MC, Rodriguez M, Martinez J, Rozé C. Large and prolonged in vivo response of pancreatic secretion to phenylethylamide and phenylethylester derivatives of Boc-[Nle28-Nle31]CCK(26-33) in the rat. Peptides. 1992 Nov-Dec;13(6):1127-32. PubMed PMID: 1494494. 2: Gue M, Junien JL, Del Rio C, Bueno L. Neuropeptide Y and sigma ligand (JO 1784) suppress stress-induced colonic motor disturbances in rats through sigma and cholecystokinin receptors. J Pharmacol Exp Ther. 1992 Jun;261(3):850-5. PubMed PMID: 1318376. 3: Botella A, Delvaux M, Berry P, Frexinos J, Bueno L. Cholecystokinin and gastrin induce cell contraction in pig ileum by interacting with different receptor subtypes. Gastroenterology. 1992 Mar;102(3):779-86. PubMed PMID: 1537515. 4: Orosco M, Gourch A, Rodriguez M, Martinez J, Jacquot C, Cohen Y. Comparative activity of two cholecystokinin analogues with partial agonist activity: effects on food intake and brain monoamines. Peptides. 1990 Sep-Oct;11(5):873-7. PubMed PMID: 2284198.