SEN461 | CAS#1287727-28-9 | Wnt inhibitor

MedKoo Cat#: 562959 | Name: SEN461

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SEN461 is a Wnt inhibitor/Axin stabilizer.

Chemical Structure

SEN461

CAS#1287727-28-9

Theoretical Analysis

MedKoo Cat#: 562959

Name: SEN461

CAS#: 1287727-28-9

Chemical Formula: C25H34N4O6

Exact Mass: 486.2478

Molecular Weight: 486.56

Elemental Analysis: C, 61.71; H, 7.04; N, 11.51; O, 19.73

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

SEN461; SEN-461; SEN 461;

IUPAC/Chemical Name

trans-6-Methoxy-3-{4-[4-(2-methoxy-acetyl)-piperazine-1-carbonyl]-cyclohexylmethyl}-1-methyl-1H-quinazoline-2,4-dione

InChi Key

CYIHQUXKBWFESS-IYARVYRRSA-N

InChi Code

InChI=1S/C25H34N4O6/c1-26-21-9-8-19(35-3)14-20(21)24(32)29(25(26)33)15-17-4-6-18(7-5-17)23(31)28-12-10-27(11-13-28)22(30)16-34-2/h8-9,14,17-18H,4-7,10-13,15-16H2,1-3H3/t17-,18-

SMILES Code

O=C(N1C[C@H]2CC[C@H](C(N3CCN(C(COC)=O)CC3)=O)CC2)N(C)C4=C(C=C(OC)C=C4)C1=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 486.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Nencini A, Pratelli C, Quinn JM, Salerno M, Tunici P, De Robertis A, Valensin S, Mennillo F, Rossi M, Bakker A, Benicchi T, Cappelli F, Turlizzi E, Nibbio M, Caradonna NP, Zanelli U, Andreini M, Magnani M, Varrone M. Structure-activity relationship and properties optimization of a series of quinazoline-2,4-diones as inhibitors of the canonical Wnt pathway. Eur J Med Chem. 2015 May 5;95:526-45. doi: 10.1016/j.ejmech.2015.03.055. Epub 2015 Mar 25. PubMed PMID: 25847770. 2: De Robertis A, Mennillo F, Rossi M, Valensin S, Tunici P, Mori E, Caradonna N, Varrone M, Salerno M. Human Sarcoma growth is sensitive to small-molecule mediated AXIN stabilization. PLoS One. 2014 May 19;9(5):e97847. doi: 10.1371/journal.pone.0097847. eCollection 2014. PubMed PMID: 24842792; PubMed Central PMCID: PMC4026528. 3: De Robertis A, Valensin S, Rossi M, Tunici P, Verani M, De Rosa A, Giordano C, Varrone M, Nencini A, Pratelli C, Benicchi T, Bakker A, Hill J, Sangthongpitag K, Pendharkar V, Liu B, Ng FM, Then SW, Jing Tai S, Cheong SM, He X, Caricasole A, Salerno M. Identification and characterization of a small-molecule inhibitor of Wnt signaling in glioblastoma cells. Mol Cancer Ther. 2013 Jul;12(7):1180-9. doi: 10.1158/1535-7163.MCT-12-1176-T. Epub 2013 Apr 25. PubMed PMID: 23619303; PubMed Central PMCID: PMC3707945.