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MedKoo Cat#: 596784 | Name: GS-566500

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GS-566500 is a Sofosbuvir metabolite.

Chemical Structure

GS-566500
GS-566500
CAS#1233335-78-8

Theoretical Analysis

MedKoo Cat#: 596784

Name: GS-566500

CAS#: 1233335-78-8

Chemical Formula: C13H19FN3O9P

Exact Mass: 411.0843

Molecular Weight: 411.27

Elemental Analysis: C, 37.97; H, 4.66; F, 4.62; N, 10.22; O, 35.01; P, 7.53

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
GS-566500; GS 566500; GS566500; psi-352707; psi 352707; psi352707;
IUPAC/Chemical Name
((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)oxy)(methoxy)phosphoryl)-L-alanine
InChi Key
CODZREZPJSPBGG-TWAJDPLASA-N
InChi Code
InChI=1S/C13H19FN3O9P/c1-6(9(20)21)16-27(23,24-3)26-10-8(19)13(2,14)11(25-10)17-5-4-7(18)15-12(17)22/h4-6,8,10-11,19H,1-3H3,(H,16,23)(H,20,21)(H,15,18,22)/t6-,8+,10+,11+,13+,27?/m0/s1
SMILES Code
C[C@H](NP(O[C@H]1O[C@@H](N(C(N2)=O)C=CC2=O)[C@](C)(F)[C@@H]1O)(OC)=O)C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 411.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Custodio JM, Chuck SK, Chu H, Cao H, Ma G, Flaherty J, Ling J, Kearney BP. Lack of clinically important PK interaction between coformulated ledipasvir/sofosbuvir and rilpivirine/emtricitabine/tenofovir alafenamide. Pharmacol Res Perspect. 2017 Oct;5(5). doi: 10.1002/prp2.353. PubMed PMID: 28971607; PubMed Central PMCID: PMC5625157. 2: Lawitz E, Rodriguez-Torres M, Denning JM, Albanis E, Cornpropst M, Berrey MM, Symonds WT. Pharmacokinetics, pharmacodynamics, and tolerability of GS-9851, a nucleotide analog polymerase inhibitor, following multiple ascending doses in patients with chronic hepatitis C infection. Antimicrob Agents Chemother. 2013 Mar;57(3):1209-17. doi: 10.1128/AAC.01263-12. Epub 2012 Dec 21. PubMed PMID: 23263000; PubMed Central PMCID: PMC3591915. 3: Denning J, Cornpropst M, Flach SD, Berrey MM, Symonds WT. Pharmacokinetics, safety, and tolerability of GS-9851, a nucleotide analog polymerase inhibitor for hepatitis C virus, following single ascending doses in healthy subjects. Antimicrob Agents Chemother. 2013 Mar;57(3):1201-8. doi: 10.1128/AAC.01262-12. Epub 2012 Dec 21. PubMed PMID: 23262999; PubMed Central PMCID: PMC3591883.