Polyalanine | CAS#25191-17-7 | bioactive chemical

MedKoo Cat#: 596772 | Name: Polyalanine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Polyalanine is a bioactive chemical.

Chemical Structure

Polyalanine

CAS#25191-17-7

Theoretical Analysis

MedKoo Cat#: 596772

Name: Polyalanine

CAS#: 25191-17-7

Chemical Formula: C3H7NO2

Exact Mass: 89.0477

Molecular Weight: 89.09

Elemental Analysis: C, 40.44; H, 7.92; N, 15.72; O, 35.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Polyalanine; Poly-DL-alanine; Poly-L-alanine;

IUPAC/Chemical Name

L-alanine

InChi Key

QNAYBMKLOCPYGJ-REOHCLBHSA-N

InChi Code

InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1

SMILES Code

O=C(O)[C@H](C)N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 89.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Naito A, Tasei Y, Nishimura A, Asakura T. Unusual Dynamics of Alanine Residues in Polyalanine Regions with Staggered Packing Structure of Samia Cynthia Ricini Silk Fiber in Dry and Hydrated States Studied by (13)C Solid-State NMR and Molecular Dynamics Simulation. J Phys Chem B. 2018 Jun 5. doi: 10.1021/acs.jpcb.8b03509. [Epub ahead of print] PubMed PMID: 29870250. 2: Zerze GH, Khan MN, Stillinger FH, Debenedetti PG. Computational Investigation of the Effect of Backbone Chiral Inversions on Polypeptide Structure. J Phys Chem B. 2018 May 24. doi: 10.1021/acs.jpcb.8b03157. [Epub ahead of print] PubMed PMID: 29793336. 3: Gorman KM, Cary H, Gaffney L, Forman E, Waldron D, Al-Delami F, Lynch BJ, King MD, Allen NM. Status dystonicus due to missense variant in ARX: Diagnosis and management. Eur J Paediatr Neurol. 2018 May 3. pii: S1090-3798(17)31999-2. doi: 10.1016/j.ejpn.2018.04.015. [Epub ahead of print] PubMed PMID: 29778428. 4: Katwa U, D'Gama AM, Qualls AE, Donovan LM, Heffernan J, Shi J, Agrawal PB. Atypical presentations associated with non-polyalanine repeat PHOX2B mutations. Am J Med Genet A. 2018 Apr 28. doi: 10.1002/ajmg.a.38720. [Epub ahead of print] PubMed PMID: 29704303. 5: Liu H, Cheng Y, Chen J, Chang F, Wang J, Ding J, Chen X. Component effect of stem cell-loaded thermosensitive polypeptide hydrogels on cartilage repair. Acta Biomater. 2018 Jun;73:103-111. doi: 10.1016/j.actbio.2018.04.035. Epub 2018 Apr 21. PubMed PMID: 29684624. 6: Ventura F, Barranco R, Bachetti T, Nozza P, Fulcheri E, Palmieri A, Ceccherini I. Medico-legal investigation in an explicable case of congenital central hypoventilation syndrome due to a rare variant of the PHOX2B gene. J Forensic Leg Med. 2018 Apr 17;58:1-5. doi: 10.1016/j.jflm.2018.04.009. [Epub ahead of print] PubMed PMID: 29679838. 7: Wojciechowski D, Thiemann S, Schaal C, Rahtz A, de la Roche J, Begemann B, Becher T, Fischer M. Activation of renal ClC-K chloride channels depends on an intact N terminus of their accessory subunit barttin. J Biol Chem. 2018 Jun 1;293(22):8626-8637. doi: 10.1074/jbc.RA117.000860. Epub 2018 Apr 19. PubMed PMID: 29674316; PubMed Central PMCID: PMC5986197. 8: Dubos A, Meziane H, Iacono G, Curie A, Riet F, Martin C, Loaëc N, Birling MC, Selloum M, Normand E, Pavlovic G, Sorg T, Stunnenberg HG, Chelly J, Humeau Y, Friocourt G, Hérault Y. A new mouse model of ARX dup24 recapitulates the patients' behavioral and fine motor alterations. Hum Mol Genet. 2018 Jun 15;27(12):2138-2153. doi: 10.1093/hmg/ddy122. PubMed PMID: 29659809. 9: Zhang L, Wang H, E W. Reinforced dynamics for enhanced sampling in large atomic and molecular systems. J Chem Phys. 2018 Mar 28;148(12):124113. doi: 10.1063/1.5019675. PubMed PMID: 29604808. 10: Tanizawa K, Chin K. Genetic factors in sleep-disordered breathing. Respir Investig. 2018 Mar;56(2):111-119. doi: 10.1016/j.resinv.2017.11.012. Epub 2017 Dec 23. Review. PubMed PMID: 29548648. 11: Usón I, Sheldrick GM. An introduction to experimental phasing of macromolecules illustrated by SHELX; new autotracing features. Acta Crystallogr D Struct Biol. 2018 Feb 1;74(Pt 2):106-116. doi: 10.1107/S2059798317015121. Epub 2018 Feb 1. PubMed PMID: 29533236; PubMed Central PMCID: PMC5947774. 12: Caballero I, Sammito M, Millán C, Lebedev A, Soler N, Usón I. ARCIMBOLDO on coiled coils. Acta Crystallogr D Struct Biol. 2018 Mar 1;74(Pt 3):194-204. doi: 10.1107/S2059798317017582. Epub 2018 Mar 2. PubMed PMID: 29533227; PubMed Central PMCID: PMC5947760. 13: Tsuchiya K, Ishii T, Masunaga H, Numata K. Spider dragline silk composite films doped with linear and telechelic polyalanine: Effect of polyalanine on the structure and mechanical properties. Sci Rep. 2018 Feb 26;8(1):3654. doi: 10.1038/s41598-018-21970-1. PubMed PMID: 29483536; PubMed Central PMCID: PMC5827030. 14: Pimentel CP, Cortinhas-Alves EA, de Oliveira EHC, Santana-da-Silva LC. Does the Polymorphism in the Length of the Polyalanine Tract of FOXE1 Gene Influence the Risk of Thyroid Dysgenesis Occurrence? J Thyroid Res. 2017;2017:2793205. doi: 10.1155/2017/2793205. Epub 2017 Nov 28. PubMed PMID: 29479488; PubMed Central PMCID: PMC5727785. 15: Kasahara K, Sakuraba S, Fukuda I. Enhanced Sampling of Molecular Dynamics Simulations of a Polyalanine Octapeptide: Effects of the Periodic Boundary Conditions on Peptide Conformation. J Phys Chem B. 2018 Mar 8;122(9):2495-2503. doi: 10.1021/acs.jpcb.7b10830. Epub 2018 Feb 22. PubMed PMID: 29439570. 16: Li F, Chai P, Fan J, Wang X, Lu W, Li J, Ge S, Jia R, Zhang H, Fan X. A Novel FOXL2 Mutation Implying Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Type I. Cell Physiol Biochem. 2018;45(1):203-211. doi: 10.1159/000486358. Epub 2018 Jan 15. PubMed PMID: 29339661. 17: Hall DA, Berry-Kravis E. Fragile X syndrome and fragile X-associated tremor ataxia syndrome. Handb Clin Neurol. 2018;147:377-391. doi: 10.1016/B978-0-444-63233-3.00025-7. PubMed PMID: 29325626. 18: Ganguly P, Boserman P, van der Vegt NFA, Shea JE. Trimethylamine N-oxide Counteracts Urea Denaturation by Inhibiting Protein-Urea Preferential Interaction. J Am Chem Soc. 2018 Jan 10;140(1):483-492. doi: 10.1021/jacs.7b11695. Epub 2017 Dec 22. PubMed PMID: 29214802. 19: Ross-Naylor JA, Mijajlovic M, Zhang H, Biggs MJ. Characterizing the Switching Transitions of an Adsorbed Peptide by Mapping the Potential Energy Surface. J Phys Chem B. 2017 Dec 28;121(51):11455-11464. doi: 10.1021/acs.jpcb.7b10319. Epub 2017 Dec 19. PubMed PMID: 29210265. 20: Di Lascio S, Benfante R, Di Zanni E, Cardani S, Adamo A, Fornasari D, Ceccherini I, Bachetti T. Structural and functional differences in PHOX2B frameshift mutations underlie isolated or syndromic congenital central hypoventilation syndrome. Hum Mutat. 2018 Feb;39(2):219-236. doi: 10.1002/humu.23365. Epub 2017 Nov 21. PubMed PMID: 29098737; PubMed Central PMCID: PMC5846889.