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MedKoo Cat#: 596749 | Name: CP-18 F-18

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CP-18 F-18 is a DEVD (the caspase 3 substrate recognition motif) containing substrate-based compound as an imaging tracer for caspase-3 activity in apoptotic cells.

Chemical Structure

CP-18 F-18
CP-18 F-18
CAS#1193087-67-0

Theoretical Analysis

MedKoo Cat#: 596749

Name: CP-18 F-18

CAS#: 1193087-67-0

Chemical Formula: C46H7318FN10O23

Exact Mass: 1151.4859

Molecular Weight: 1152.13

Elemental Analysis: C, 47.95; H, 6.39; F, 1.56; N, 12.16; O, 31.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
CP-18 F-18; CP 18 F-18; CP18 F-18; (18F)-CP18;
IUPAC/Chemical Name
(18S,21S,24S,27S,30S)-27-(2-carboxyethyl)-21-(carboxymethyl)-30-((2S,3R,4R,5R,6S)-6-((2-(4-(3-(fluoro-18F)propyl)-1H-1,2,3-triazol-1-yl)acetamido)methyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxamido)-24-isopropyl-18-methyl-17,20,23,26,29-pentaoxo-4,7,10,13-tetraoxa-16,19,22,25,28-pentaazadotriacontanedioic acid
InChi Key
SZXPYKHOFVWUDG-XXVAWOGHSA-N
InChi Code
InChI=1S/C46H73FN10O23/c1-24(2)36(45(74)52-28(19-34(63)64)43(72)50-25(3)41(70)48-10-12-77-14-16-79-18-17-78-15-13-76-11-8-33(61)62)54-42(71)27(6-7-32(59)60)51-44(73)29(20-35(65)66)53-46(75)40-39(69)38(68)37(67)30(80-40)21-49-31(58)23-57-22-26(55-56-57)5-4-9-47/h22,24-25,27-30,36-40,67-69H,4-21,23H2,1-3H3,(H,48,70)(H,49,58)(H,50,72)(H,51,73)(H,52,74)(H,53,75)(H,54,71)(H,59,60)(H,61,62)(H,63,64)(H,65,66)/t25-,27-,28-,29-,30-,36-,37-,38+,39+,40-/m0/s1/i47-1
SMILES Code
CC([C@@H](C(N[C@H](C(N[C@H](C(NCCOCCOCCOCCOCCC(O)=O)=O)C)=O)CC(O)=O)=O)NC([C@@H](NC([C@@H](NC([C@H]1O[C@H]([C@@H]([C@H]([C@H]1O)O)O)CNC(Cn2nnc(CCC[18F])c2)=O)=O)CC(O)=O)=O)CCC(O)=O)=O)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,152.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chen SF, Wei TZ, Rao LY, Xu MG, Dong ZL. CT-1-CP-induced ventricular electrical remodeling in mice. J Huazhong Univ Sci Technolog Med Sci. 2015 Feb;35(1):21-7. doi: 10.1007/s11596-015-1383-8. Epub 2015 Feb 12. PubMed PMID: 25673188. 2: Coleman A, Weir KA, Ware RS, Boyd RN. Relationship between communication skills and gross motor function in preschool-aged children with cerebral palsy. Arch Phys Med Rehabil. 2013 Nov;94(11):2210-7. doi: 10.1016/j.apmr.2013.03.025. Epub 2013 Apr 11. PubMed PMID: 23583864. 3: Abe Y, Tamura K, Sakata I, Ishida J, Fukuba I, Matsuoka R, Shimizu S, Murakami H, Machida K. Usefulness of (18)F-FDG positron emission tomography/computed tomography for the diagnosis of pyothorax-associated lymphoma: A report of three cases. Oncol Lett. 2010 Sep;1(5):833-836. Epub 2010 Sep 1. PubMed PMID: 22966389; PubMed Central PMCID: PMC3436407. 4: Thie JA. Volume-normalized uptake rates with robust transportability from PET dual-time and Patlak analyses. Mol Imaging Biol. 2010 Oct;12(5):479-87. doi: 10.1007/s11307-009-0280-6. Epub 2009 Dec 1. PubMed PMID: 19949982. 5: Aldughpassi A, Wolever TM. Effect of coffee and tea on the glycaemic index of foods: no effect on mean but reduced variability. Br J Nutr. 2009 May;101(9):1282-5. PubMed PMID: 19434800. 6: González-Gándara C, Trinidad-Martínez Sdel C, Chávez-Morales VM. [Ichthyofauna associated to Thalassia testudinum at Lobos reef, Veracruz, Mexico: diversity and abundance]. Rev Biol Trop. 2006 Mar;54(1):189-94. Spanish. PubMed PMID: 18457187. 7: Asakura H, Togami T, Mitani M, Takashima H, Yokoe K, Yamamoto Y, Nishiyama Y, Monden T, Toyama Y, Ohkawa M. Usefulness of FDG-PET imaging for the radiotherapy treatment planning of pyothorax-associated lymphoma. Ann Nucl Med. 2005 Dec;19(8):725-8. PubMed PMID: 16445000. 8: Nakai H, Matsuda H, Takara E, Diksic M, Meyer E, Yamamoto YL. Simultaneous in vivo measurement of lumped constant and rate constants in experimental cerebral ischemia using F-18 FDG. Stroke. 1987 Jan-Feb;18(1):158-67. PubMed PMID: 3810749.