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MedKoo Cat#: 596748 | Name: TRP-601

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TRP-601 is a caspase inhibitor.

Chemical Structure

TRP-601
TRP-601
CAS#1094569-02-4

Theoretical Analysis

MedKoo Cat#: 596748

Name: TRP-601

CAS#: 1094569-02-4

Chemical Formula: C40H48F2N6O11

Exact Mass: 826.3349

Molecular Weight: 826.85

Elemental Analysis: C, 58.10; H, 5.85; F, 4.60; N, 10.16; O, 21.28

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
TRP-601; TRP 601; TRP601;
IUPAC/Chemical Name
methyl (3S,6S,9S)-11-((S)-1-amino-1-oxopropan-2-yl)-12-(2-(2,6-difluorophenoxy)acetyl)-3,9-diisopropyl-6-(2-methoxy-2-oxoethyl)-1,4,7,10-tetraoxo-1-(quinolin-2-yl)-2,5,8,11-tetraazatetradecan-14-oate
InChi Key
XTUDAUVBWTZHBO-NYAWMRQXSA-N
InChi Code
InChI=1S/C40H48F2N6O11/c1-20(2)33(46-37(53)27-16-15-23-11-8-9-14-26(23)44-27)39(55)45-28(17-31(50)57-6)38(54)47-34(21(3)4)40(56)48(22(5)36(43)52)29(18-32(51)58-7)30(49)19-59-35-24(41)12-10-13-25(35)42/h8-16,20-22,28-29,33-34H,17-19H2,1-7H3,(H2,43,52)(H,45,55)(H,46,53)(H,47,54)/t22-,28-,29?,33-,34-/m0/s1
SMILES Code
C[C@@H](C(N)=O)N(C([C@H](C(C)C)NC([C@H](CC(OC)=O)NC([C@H](C(C)C)NC(C1=NC2=CC=CC=C2C=C1)=O)=O)=O)=O)C(CC(OC)=O)C(COC3=C(F)C=CC=C3F)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 826.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sifringer M, Bendix I, Börner C, Endesfelder S, von Haefen C, Kalb A, Holifanjaniaina S, Prager S, Schlager GW, Keller M, Jacotot E, Felderhoff-Mueser U. Prevention of neonatal oxygen-induced brain damage by reduction of intrinsic apoptosis. Cell Death Dis. 2012 Jan 12;3:e250. doi: 10.1038/cddis.2011.133. PubMed PMID: 22237207; PubMed Central PMCID: PMC3270267. 2: Chauvier D, Renolleau S, Holifanjaniaina S, Ankri S, Bezault M, Schwendimann L, Rousset C, Casimir R, Hoebeke J, Smirnova M, Debret G, Trichet AP, Carlsson Y, Wang X, Bernard E, Hébert M, Rauzier JM, Matecki S, Lacampagne A, Rustin P, Mariani J, Hagberg H, Gressens P, Charriaut-Marlangue C, Jacotot E. Targeting neonatal ischemic brain injury with a pentapeptide-based irreversible caspase inhibitor. Cell Death Dis. 2011 Sep 1;2:e203. doi: 10.1038/cddis.2011.87. PubMed PMID: 21881605; PubMed Central PMCID: PMC3186905.