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MedKoo Cat#: 562941 | Name: PAO-PDT

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PAO-PDT is a highly selective small molecule inhibitor of thioredoxin reductase (TrxR).

Chemical Structure

PAO-PDT
PAO-PDT
CAS#256348-71-7

Theoretical Analysis

MedKoo Cat#: 562941

Name: PAO-PDT

CAS#: 256348-71-7

Chemical Formula: C9H12AsNS2

Exact Mass: 272.9627

Molecular Weight: 273.24

Elemental Analysis: C, 39.56; H, 4.43; As, 27.42; N, 5.13; S, 23.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PAO-PDT; PAO PDT; PAOPDT;
IUPAC/Chemical Name
2-(4-Aminophenyl)-1,3,2-dithiarsinane
InChi Key
WONBTYJJKXSAKA-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H12AsNS2/c11-9-4-2-8(3-5-9)10-12-6-1-7-13-10/h2-5H,1,6-7,11H2
SMILES Code
NC1=CC=C([As]2SCCCS2)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 273.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Fan XY, Liu YJ, Chen K, Jiang FL, Hu YJ, Liu D, Liu Y, Ge YS. Organic arsenicals target thioredoxin reductase followed by oxidative stress and mitochondrial dysfunction resulting in apoptosis. Eur J Med Chem. 2018 Jan 1;143:1090-1102. doi: 10.1016/j.ejmech.2017.05.022. Epub 2017 May 6. PubMed PMID: 29150332. 2: Liu Y, Duan D, Yao J, Zhang B, Peng S, Ma H, Song Y, Fang J. Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase. J Med Chem. 2014 Jun 26;57(12):5203-11. doi: 10.1021/jm500221p. Epub 2014 Jun 11. PubMed PMID: 24867309.