IUPAC/Chemical Name
(2R,6S,7R)-6-amino-2-((S)-3-amino-N-((S)-3-amino-1-((S)-3-amino-2-phenylpropanamido)-1-oxopropan-2-yl)-3-hydroxypropanamido)-9-((2-((3-((4-aminobutyl)amino)propyl)amino)-2-oxoethyl)amino)-7-hydroxy-9-oxononanoic acid
InChi Key
IPMMZHSSDSNSRO-XBGJXXGBSA-N
InChi Code
InChI=1S/C33H58N10O9/c34-12-4-5-13-39-14-7-15-40-29(47)20-41-28(46)16-26(44)23(37)10-6-11-24(33(51)52)43(30(48)17-27(38)45)25(19-36)32(50)42-31(49)22(18-35)21-8-2-1-3-9-21/h1-3,8-9,22-27,39,44-45H,4-7,10-20,34-38H2,(H,40,47)(H,41,46)(H,51,52)(H,42,49,50)/t22-,23+,24-,25+,26-,27+/m1/s1
SMILES Code
O=C(NC([C@@H](C1=CC=CC=C1)CN)=O)[C@H](CN)N(C(C[C@H](O)N)=O)[C@@H](C(O)=O)CCC[C@H](N)[C@H](O)CC(NCC(NCCCNCCCCN)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
738.88
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Czajgucki Z, Andruszkiewicz R, Kamysz W. Structure activity relationship studies on the antimicrobial activity of novel edeine A and D analogues. J Pept Sci. 2006 Oct;12(10):653-62. PubMed PMID: 16847816.
3: Gumieniak J, Andruszkiewicz R, Czerwiński A, Grzybowska J, Borowski E. Synthesis of the decarboxy analog of edeine D. J Antibiot (Tokyo). 1983 Sep;36(9):1239-41. PubMed PMID: 6415032.
4: Czerwiński A, Wojciechowska H, Andruszkiewicz R, Grzybowska J, Gumieniak J, Borowski E. Total synthesis of edeine D. J Antibiot (Tokyo). 1983 Aug;36(8):1001-6. PubMed PMID: 6415028.
5: Wojciechowska H, Zgoda W, Borowski E, Dziegielewski K, Ulikowski S. The antibiotic edeine. XII. Isolation and structure of edeine F. J Antibiot (Tokyo). 1983 Jul;36(7):793-8. PubMed PMID: 6615592.
6: Wojciechowska H, Ciarkowski J, Chmara H, Borowski E. The antibiotic edeine. IX. The isolation and the composition of edeine D. Experientia. 1972 Dec 15;28(12):1423-4. PubMed PMID: 4654193.
