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MedKoo Cat#: 596729 | Name: Capnoidine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Capnoidine is a potential new anti-inflammatory drug lead candidate for diseases where current standard-of-care often fails and is associated with major side effects. It also validates the traditional uses of C. dubia against inflammatory conditions and underlines the value of pursuing bioactive compounds derived from traditionally used ethnobotanical medicines.

Chemical Structure

Capnoidine
Capnoidine
CAS#485-50-7

Theoretical Analysis

MedKoo Cat#: 596729

Name: Capnoidine

CAS#: 485-50-7

Chemical Formula: C20H17NO6

Exact Mass: 367.1056

Molecular Weight: 367.35

Elemental Analysis: C, 65.39; H, 4.66; N, 3.81; O, 26.13

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Capnoidine; l-Adlumidine; l-Capnoidine; (-)-Adlumidine;
IUPAC/Chemical Name
(R)-6-((R)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-[1,3]dioxolo[4,5-e]isobenzofuran-8(6H)-one
InChi Key
IYGYMKDQCDOMRE-QZTJIDSGSA-N
InChi Code
InChI=1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18-/m1/s1
SMILES Code
O=C1O[C@@H]([C@@H]2N(C)CCC3=CC4=C(OCO4)C=C23)C5=CC=C(OCO6)C6=C51
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 367.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shepherd C, Giacomin P, Navarro S, Miller C, Loukas A, Wangchuk P. A medicinal plant compound, capnoidine, prevents the onset of inflammation in a mouse model of colitis. J Ethnopharmacol. 2018 Jan 30;211:17-28. doi: 10.1016/j.jep.2017.09.024. Epub 2017 Sep 21. PubMed PMID: 28942135. 2: Niu X, Li W, Xu H, Liu X, Qi L. Simultaneous quantification of 11 isoquinoline alkaloids in Corydalis impatiens (Pall.) Fisch by HPLC. J Sep Sci. 2013 Jul;36(13):2090-5. doi: 10.1002/jssc.201300036. Epub 2013 Jun 10. PubMed PMID: 23610009. 3: Wangchuk P, Keller PA, Pyne SG, Willis AC, Kamchonwongpaisan S. Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia. J Ethnopharmacol. 2012 Aug 30;143(1):310-3. doi: 10.1016/j.jep.2012.06.037. Epub 2012 Jul 14. PubMed PMID: 22796506. 4: Preininger V, Thakur RS, Santavý F. Isolation and chemistry of alkaloids from plants of the family Papaveraceae LXVII: Corydalis cava (L.) Sch. et K. (C. tuberosa DC). J Pharm Sci. 1976 Feb;65(2):294-6. PubMed PMID: 1255467.