SOMCL-863 | CAS#1452310-87-0 | c-Met inhibitor

MedKoo Cat#: 562936 | Name: SOMCL-863

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SOMCL-863 is a selective and orally bioavailable c-Met inhibitor that exhibits antitumor activity both in vitro and in vivo.

Chemical Structure

SOMCL-863

CAS#1452310-87-0

Theoretical Analysis

MedKoo Cat#: 562936

Name: SOMCL-863

CAS#: 1452310-87-0

Chemical Formula: C23H24F3N5O3

Exact Mass: 475.1831

Molecular Weight: 475.47

Elemental Analysis: C, 58.10; H, 5.09; F, 11.99; N, 14.73; O, 10.09

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

SOMCL-863; SOMCL 863; SOMCL863;

IUPAC/Chemical Name

2-(4-(5-((3-Nitrobenzyl)amino)-7-(trifluoromethyl)quinolin-3-yl)piperazin-1-yl)ethanol

InChi Key

IEQYRWPMNVPDLX-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H24F3N5O3/c24-23(25,26)17-11-21(27-14-16-2-1-3-18(10-16)31(33)34)20-13-19(15-28-22(20)12-17)30-6-4-29(5-7-30)8-9-32/h1-3,10-13,15,27,32H,4-9,14H2

SMILES Code

FC(C1=CC(NCC2=CC=CC([N+]([O-])=O)=C2)=C3C=C(N4CCN(CCO)CC4)C=NC3=C1)(F)F

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 475.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wang L, Ai J, Shen Y, Zhang H, Peng X, Huang M, Zhang A, Ding J, Geng M. SOMCL-863, a novel, selective and orally bioavailable small-molecule c-Met inhibitor, exhibits antitumor activity both in vitro and in vivo. Cancer Lett. 2014 Aug 28;351(1):143-50. doi: 10.1016/j.canlet.2014.05.012. Epub 2014 May 28. PubMed PMID: 24880078.