Glutamic Acid | CAS#56-86-0 | amino acid

MedKoo Cat#: 596723 | Name: Glutamic Acid

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Glutamic Acid is a non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.

Chemical Structure

Glutamic Acid

CAS#56-86-0

Theoretical Analysis

MedKoo Cat#: 596723

Name: Glutamic Acid

CAS#: 56-86-0

Chemical Formula: C5H9NO4

Exact Mass: 147.0532

Molecular Weight: 147.13

Elemental Analysis: C, 40.82; H, 6.17; N, 9.52; O, 43.50

Price and Availability

Size	Price	Availability	Quantity
25g	USD 250.00	2 Weeks
100g	USD 450.00	2 Weeks

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Synonym

Glutamic Acid; Glutamicol; L-glutamic acid; Glutamidex; (S)-Glutamic acid

IUPAC/Chemical Name

L-glutamic acid

InChi Key

WHUUTDBJXJRKMK-VKHMYHEASA-N

InChi Code

InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1

SMILES Code

N[C@@H](CCC(O)=O)C(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

In vitro activity:

As shown in Figure 2 and Figure 3, the levels of methotrexate pentaglutamate (MTX-PG5) were significantly higher in Acute Lymphoblastic Leukemia cells treated with 20 mM glutamic acid compared with those of cells that were exposed only to MTX and MTX plus 10 mM glutamic acid. Reference: Medicina (Kaunas). 2019 Nov 26;55(12):758. https://pubmed.ncbi.nlm.nih.gov/31779260/

In vivo activity:

Surprisingly, 1% and 10% GA (glutamic acid) accelerated hair growth after 14 days of topical treatment (Fig. 3a). Using photomicrographs, this study also showed that GA increased external root sheath across all GA concentrations (Fig. 3b, Supplementary Fig. 1f.) with no hyperkeratosis effect. This study also consistently identified increased BrdU positive cells in the hair follicles and epidermal layer after 14-days of GA topical treatment (Figs. 3c, c,44f). Reference: Sci Rep. 2021 Jul 29;11(1):15453. https://pubmed.ncbi.nlm.nih.gov/34326383/

	Solvent	mg/mL	mM
Solubility
	Water	6.3	42.48

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 147.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Mendoza-Santiago A, Becerra E, Garay E, Bah M, Berumen-Segura L, Escobar-Cabrera J, Hernández-Pérez A, García-Alcocer G. Glutamic Acid Increased Methotrexate Polyglutamation and Cytotoxicity in a CCRF-SB Acute Lymphoblastic Leukemia Cell Line. Medicina (Kaunas). 2019 Nov 26;55(12):758. doi: 10.3390/medicina55120758. PMID: 31779260; PMCID: PMC6956105. 2. Jara CP, de Andrade Berti B, Mendes NF, Engel DF, Zanesco AM, Pereira de Souza GF, de Medeiros Bezerra R, de Toledo Bagatin J, Maria-Engler SS, Morari J, Velander WH, Velloso LA, Araújo EP. Glutamic acid promotes hair growth in mice. Sci Rep. 2021 Jul 29;11(1):15453. doi: 10.1038/s41598-021-94816-y. PMID: 34326383; PMCID: PMC8322389.

In vitro protocol:

In vivo protocol:

1. Jara CP, de Andrade Berti B, Mendes NF, Engel DF, Zanesco AM, Pereira de Souza GF, de Medeiros Bezerra R, de Toledo Bagatin J, Maria-Engler SS, Morari J, Velander WH, Velloso LA, Araújo EP. Glutamic acid promotes hair growth in mice. Sci Rep. 2021 Jul 29;11(1):15453. doi: 10.1038/s41598-021-94816-y. PMID: 34326383; PMCID: PMC8322389.

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