Synonym
L 738372; L-738372; L738372; L-738,372; L 738,372; L738,372;
IUPAC/Chemical Name
(S)-4-cyclopropyl-4-(pyridin-2-ylethynyl)-3,4-dihydroquinazolin-2(1H)-one
InChi Key
GRKPBOOXGCBIQK-GOSISDBHSA-N
InChi Code
InChI=1S/C18H15N3O/c22-17-20-16-7-2-1-6-15(16)18(21-17,13-8-9-13)11-10-14-5-3-4-12-19-14/h1-7,12-13H,8-9H2,(H2,20,21,22)/t18-/m1/s1
SMILES Code
O=C1NC2=C(C=CC=C2)[C@@](C#CC3=NC=CC=C3)(C4CC4)N1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
289.33
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Wang T, Grinberg N, Bicker G, Tway P, Thompson K. High-performance liquid chromatographic separation of an HIV-1 reverse transcriptase inhibitor and its enantiomer. J Chromatogr A. 1996 Jul 12;738(2):290-4. PubMed PMID: 8696508.
2: Prueksaritanont T, Balani SK, Dwyer LM, Ellis JD, Kauffman LR, Varga SL, Pitzenberger SM, Theoharides AD. Species differences in the metabolism of a potent HIV-1 reverse transcriptase inhibitor L-738,372. In vivo and in vitro studies in rats, dogs, monkeys, and human. Drug Metab Dispos. 1995 Jul;23(7):688-95. PubMed PMID: 7587955.
3: Carroll SS, Stahlhut M, Geib J, Olsen DB. Inhibition of HIV-1 reverse transcriptase by a quinazolinone and comparison with inhibition by pyridinones. Differences in the rates of inhibitor binding and in synergistic inhibition with nucleoside analogs. J Biol Chem. 1994 Dec 23;269(51):32351-7. PubMed PMID: 7528214.
