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MedKoo Cat#: 596664 | Name: L 699333

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L 699333 is a 5-lipoxygenase inhibitor.

Chemical Structure

L 699333
L 699333
CAS#155238-60-1

Theoretical Analysis

MedKoo Cat#: 596664

Name: L 699333

CAS#: 155238-60-1

Chemical Formula: C36H35ClN2O4S

Exact Mass: 626.2006

Molecular Weight: 627.19

Elemental Analysis: C, 68.94; H, 5.63; Cl, 5.65; N, 4.47; O, 10.20; S, 5.11

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
L 699333; L-699333; L699333; L-699,333; L 699,333; L699,333;
IUPAC/Chemical Name
(R)-2-(2-((S)-1-(4-chlorobenzyl)-4-methyl-6-((5-phenylpyridin-2-yl)methoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl)ethoxy)butanoic acid
InChi Key
JCBSPQXPBDDSEZ-JPQMRUPTSA-N
InChi Code
InChI=1S/C36H35ClN2O4S/c1-3-32(36(40)41)42-18-17-31-35-34-29(19-23(2)44-35)33(16-15-30(34)39(31)21-24-9-12-27(37)13-10-24)43-22-28-14-11-26(20-38-28)25-7-5-4-6-8-25/h4-16,20,23,32H,3,17-19,21-22H2,1-2H3,(H,40,41)/t23-,32+/m0/s1
SMILES Code
CC[C@@H](OCCC(N1CC2=CC=C(Cl)C=C2)=C3C4=C1C=CC(OCC5=NC=C(C6=CC=CC=C6)C=C5)=C4C[C@H](C)S3)C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 627.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gupta N, Greeser MJ, Ford-Hutchinson AW. A random rapid equilibrium mechanism for leukotriene C4 synthase. Adv Exp Med Biol. 1999;469:327-32. PubMed PMID: 10667349. 2: Gupta N, Gresser MJ, Ford-Hutchinson AW. Kinetic mechanism of glutathione conjugation to leukotriene A4 by leukotriene C4 synthase. Biochim Biophys Acta. 1998 Mar 30;1391(2):157-68. PubMed PMID: 9554994. 3: Negro JM, Miralles JC, Ortiz JL, Funes E, García A. Biosynthesis inhibitors for leukotrienes in bronchial asthma. Allergol Immunopathol (Madr). 1997 Jul-Aug;25(4):209-16. Review. PubMed PMID: 9269512. 4: Hutchinson JH, Riendeau D, Brideau C, Chan C, Falgueyret JP, Guay J, Jones TR, Lépine C, Macdonald D, McFarlane CS, et al. Thiopyrano[2,3,4-cd]indoles as 5-lipoxygenase inhibitors: synthesis, biological profile, and resolution of 2-[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5 -dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic acid. J Med Chem. 1994 Apr 15;37(8):1153-64. PubMed PMID: 8164257.