Tyrphostin 47 | CAS#118409-60-2 | EGFR inhibitor

MedKoo Cat#: 591343 | Name: Tyrphostin 47

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tyrphostin 47, also known as AG-213, is a potent inhibitor of epidermal growth factor receptor (EGFR) kinase activity, with an IC₅₀ of 2.4 µM. It also inhibits platelet-derived growth factor receptor (PDGFR) and p210bcr-abl kinase activities, with IC₅₀ values of 3.5 µM and 5.9 µM, respectively. Tyrphostin 47 has been utilized in research to study the role of tyrosine kinases in cell proliferation and signal transduction pathways.

Chemical Structure

Tyrphostin 47

CAS#118409-60-2

Theoretical Analysis

MedKoo Cat#: 591343

Name: Tyrphostin 47

CAS#: 118409-60-2

Chemical Formula: C10H8N2O2S

Exact Mass: 220.0306

Molecular Weight: 220.25

Elemental Analysis: C, 54.53; H, 3.66; N, 12.72; O, 14.53; S, 14.56

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 250.00

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Related CAS #

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Synonym

Tyrphostin 47; AG-213 AG 213; AG213

IUPAC/Chemical Name

2-Propenethioamide, 2-cyano-3-(3,4-dihydroxyphenyl)-

InChi Key

ZGHQGWOETPXKLY-XVNBXDOJSA-N

InChi Code

InChI=1S/C10H8N2O2S/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+

SMILES Code

S=C(N)/C(C#N)=C/C1=CC=C(O)C(O)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 220.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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TPX2 in malignantly transformed human bronchial epithelial cells by anti-benzo[a]pyrene-7,8-diol-9,10-epoxide. Toxicology. 2008 Oct 30;252(1-3):49-55. doi: 10.1016/j.tox.2008.07.059. Epub 2008 Aug 3. PubMed PMID: 18723071. 5: Kimura N, Okegawa T, Yamazaki K, Matsuoka K. Site-specific, covalent attachment of poly(dT)-modified peptides to solid surfaces for microarrays. Bioconjug Chem. 2007 Nov-Dec;18(6):1778-85. Epub 2007 Oct 23. PubMed PMID: 17953441. 6: Diaz-Ricart M, Palomo M, Fuste B, Lopez-Vilchez I, Carbo C, Perez-Pujol S, White JG, Escolar G. Inhibition of tyrosine kinase activity prevents the adhesive and cohesive properties of platelets and the expression of procoagulant activity in response to collagen. Thromb Res. 2008;121(6):873-83. Epub 2007 Sep 27. PubMed PMID: 17904203. 7: Mielke JG, Taghibiglou C, Wang YT. Endogenous insulin signaling protects cultured neurons from oxygen-glucose deprivation-induced cell death. Neuroscience. 2006 Nov 17;143(1):165-73. Epub 2006 Sep 14. PubMed PMID: 16978790. 8: Ikeda M, Gunji Y, Sonoda H, Oshikawa S, Shimono M, Horie A, Ito K, Yamasaki S. Inhibitory effect of tyrphostin 47 on Shiga toxin-induced cell death. Eur J Pharmacol. 2006 Sep 28;546(1-3):36-9. Epub 2006 Jul 26. PubMed PMID: 16919262. 9: Grasa L, Arruebo MP, Plaza MA, Murillo MD. The role of tyrosine kinase in prostaglandin E2 and vanadate-evoked contractions in rabbit duodenum in vitro. J Physiol Pharmacol. 2006 Jun;57(2):279-89. PubMed PMID: 16845231. 10: Nakayama S, Ito Y, Sato S, Kamijo A, Liu HN, Kajioka S. Tyrosine kinase inhibitors and ATP modulate the conversion of smooth muscle L-type Ca2+ channels toward a second open state. FASEB J. 2006 Jul;20(9):1492-4. Epub 2006 May 31. PubMed PMID: 16738256. 11: Mariappa D, Siva AB, Shivaji S, Seshagiri PB. Tyrphostin-A47 inhibitable tyrosine phosphorylation of flagellar proteins is associated with distinct alteration of motility pattern in hamster spermatozoa. Mol Reprod Dev. 2006 Feb;73(2):215-25. PubMed PMID: 16220544. 12: Kuznetsova LA, Plesneva SA, Shpakov AO, Sharova TS. [Stimulating effect of insulin and epidermal growth factor on activity of protein kinase A, glucose 6-phosphate dehydrogenase and glycogen synthetase in skeletal muscles of chickens and chicken embryos]. Zh Evol Biokhim Fiziol. 2004 Jul-Aug;40(4):325-33. Russian. PubMed PMID: 15481371. 13: Ding X, Murray PA. Regulation of pulmonary venous tone in response to muscarinic receptor activation. Am J Physiol Lung Cell Mol Physiol. 2005 Jan;288(1):L131-40. Epub 2004 Sep 17. PubMed PMID: 15377494. 14: Furspan PB, Chatterjee S, Freedman RR. Increased tyrosine phosphorylation mediates the cooling-induced contraction and increased vascular reactivity of Raynaud's disease. Arthritis Rheum. 2004 May;50(5):1578-85. PubMed PMID: 15146428. 15: Kéri G, Racz G, Magyar K, Orfi L, Horváth A, Schwab R, Hegymegi BB, Szende B. Pro-apoptotic and anti-apoptotic molecules affecting pathways of signal transduction. Ann N Y Acad Sci. 2003 Dec;1010:109-12. PubMed PMID: 15033704. 16: Kent KD, Bomser JA. Bovine pituitary extract provides remarkable protection against oxidative stress in human prostate epithelial cells. In Vitro Cell Dev Biol Anim. 2003 Sep-Oct;39(8-9):388-94. PubMed PMID: 14690452. 17: Ogata Y, Nakao S, Shimizu E, Matsuda-Honjyo Y, Yamazaki M, Furuyama S, Sugiya H. Tyrosine phosphorylation is involved in Ca(2+)entry in human gingival fibroblasts. Cell Biol Int. 2003;27(8):689-93. PubMed PMID: 12867160. 18: Leffler CW, Balabanova L, Sullivan CD, Wang X, Fedinec AL, Parfenova H. Regulation of CO production in cerebral microvessels of newborn pigs. Am J Physiol Heart Circ Physiol. 2003 Jul;285(1):H292-7. Epub 2003 Mar 6. PubMed PMID: 12623784. 19: Takeda J, Tabata H, Fukuda K, Yasugi S. Involvement of the signal transduction pathway mediated by epidermal growth factor receptor in the differentiation of chicken glandular stomach. Dev Growth Differ. 2002 Dec;44(6):501-8. PubMed PMID: 12492508. 20: Belanger PH, Johnston DA, Fratti RA, Zhang M, Filler SG. Endocytosis of Candida albicans by vascular endothelial cells is associated with tyrosine phosphorylation of specific host cell proteins. Cell Microbiol. 2002 Dec;4(12):805-12. PubMed PMID: 12464011.