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MedKoo Cat#: 591339 | Name: AG 127

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AG 127 is a biochemical.

Chemical Structure

AG 127
AG 127
CAS#90947-89-0

Theoretical Analysis

MedKoo Cat#: 591339

Name: AG 127

CAS#: 90947-89-0

Chemical Formula: C10H5N3O3

Exact Mass: 215.0331

Molecular Weight: 215.17

Elemental Analysis: C, 55.82; H, 2.34; N, 19.53; O, 22.31

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AG 127; AG-127 AG127;
IUPAC/Chemical Name
Propanedinitrile, ((4-hydroxy-3-nitrophenyl)methylene)-
InChi Key
BQOURLGXLYRASY-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H5N3O3/c11-5-8(6-12)3-7-1-2-10(14)9(4-7)13(15)16/h1-4,14H
SMILES Code
N#C/C(C#N)=C/C1=CC=C(O)C([N+]([O-])=O)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 215.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Cell Calcium. 2013 Feb;53(2):125-38. doi: 10.1016/j.ceca.2012.11.004. Epub 2012 Dec 4. PubMed PMID: 23218930. 4: Turpaev K, Ermolenko M, Cresteil T, Drapier JC. Benzylidenemalononitrile compounds as activators of cell resistance to oxidative stress and modulators of multiple signaling pathways. A structure-activity relationship study. Biochem Pharmacol. 2011 Sep 1;82(5):535-47. doi: 10.1016/j.bcp.2011.05.028. Epub 2011 Jun 2. PubMed PMID: 21669191. 5: Wang WL, Hong JR, Lin GH, Liu W, Gong HY, Lu MW, Lin CC, Wu JL. Stage-specific expression of TNFα regulates bad/bid-mediated apoptosis and RIP1/ROS-mediated secondary necrosis in Birnavirus-infected fish cells. PLoS One. 2011 Feb 3;6(2):e16740. doi: 10.1371/journal.pone.0016740. PubMed PMID: 21304825; PubMed Central PMCID: PMC3033425. 6: Kim YJ, Lee CS. Tyrosine kinase inhibitor AG126 reduces 7-ketocholesterol-induced cell death by suppressing mitochondria-mediated apoptotic process. Neurochem Res. 2010 Apr;35(4):603-12. doi: 10.1007/s11064-009-0105-7. Epub 2009 Dec 3. PubMed PMID: 19957203. 7: Yuan H, Perry CN, Huang C, Iwai-Kanai E, Carreira RS, Glembotski CC, Gottlieb RA. LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection. Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H470-9. doi: 10.1152/ajpheart.01051.2008. Epub 2008 Dec 19. PubMed PMID: 19098111; PubMed Central PMCID: PMC2643899. 8: Genovese T, Mazzon E, Esposito E, Muià C, Di Paola R, Crisafulli C, Bramanti P, Cuzzocrea S. Inhibition of tyrosine kinase-mediated cellular signalling by Tyrphostins AG126 and AG556 modulates secondary damage in experimental spinal cord trauma. Neuropharmacology. 2007 Jun;52(7):1454-71. Epub 2007 Feb 12. PubMed PMID: 17418876. 9: Balachandra S, Genovese T, Mazzon E, Di Paola R, Thiemerman C, Siriwardena AK, Cuzzocrea S. Inhibition of tyrosine-kinase-mediated cellular signaling by tyrphostins AG 126 and AG556 modulates murine experimental acute pancreatitis. Surgery. 2005 Nov;138(5):913-23. PubMed PMID: 16291393. 10: Kann O, Hoffmann A, Schumann RR, Weber JR, Kettenmann H, Hanisch UK. The tyrosine kinase inhibitor AG126 restores receptor signaling and blocks release functions in activated microglia (brain macrophages) by preventing a chronic rise in the intracellular calcium level. J Neurochem. 2004 Aug;90(3):513-25. PubMed PMID: 15255929. 11: Kahlenberg JM, Dubyak GR. Differing caspase-1 activation states in monocyte versus macrophage models of IL-1beta processing and release. J Leukoc Biol. 2004 Sep;76(3):676-84. Epub 2004 Jul 7. PubMed PMID: 15240753. 12: Angstwurm K, Hanisch UK, Gassemi T, Bille MB, Prinz M, Dirnagl U, Kettenmann H, Weber JR. Tyrosine kinase inhibition reduces inflammation in the acute stage of experimental pneumococcal meningitis. Infect Immun. 2004 Jun;72(6):3294-8. PubMed PMID: 15155632; PubMed Central PMCID: PMC415676. 13: Yao YM, Cheng MH, Yao S, Liang HP, Li HY, Dong N, Yu Y, Sheng ZY. [Effects of extracellular signal-regulated kinase inhibition by AG126 on tissue tumor necrosis factor-alpha expression and multiple organ dysfunction in rats with postburn Staphylococcus aureus sepsis]. Zhonghua Wai Ke Za Zhi. 2004 Apr 7;42(7):391-5. Chinese. PubMed PMID: 15144664. 14: George J, Barshack I, Goldberg I, Keren P, Gazit A, Levitzki A, Keren G, Roth A. The effect of early and late treatment with the tyrphostin AG-556 on the progression of experimental autoimmune myocarditis. Exp Mol Pathol. 2004 Jun;76(3):234-41. PubMed PMID: 15126106. 15: Kahlenberg JM, Dubyak GR. Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release. Am J Physiol Cell Physiol. 2004 May;286(5):C1100-8. Epub 2003 Dec 24. PubMed PMID: 15075209. 16: Karakashian AA, Giltiay NV, Smith GM, Nikolova-Karakashian MN. Expression of neutral sphingomyelinase-2 (NSMase-2) in primary rat hepatocytes modulates IL-beta-induced JNK activation. FASEB J. 2004 Jun;18(9):968-70. Epub 2004 Apr 1. PubMed PMID: 15059969. 17: Rittig MG, Shaw B, Letley DP, Thomas RJ, Argent RH, Atherton JC. Helicobacter pylori-induced homotypic phagosome fusion in human monocytes is independent of the bacterial vacA and cag status. Cell Microbiol. 2003 Dec;5(12):887-99. PubMed PMID: 14641174. 18: Chatterjee PK, Patel NS, Kvale EO, Brown PA, Stewart KN, Britti D, Cuzzocrea S, Mota-Filipe H, Thiemermann C. The tyrosine kinase inhibitor tyrphostin AG126 reduces renal ischemia/reperfusion injury in the rat. Kidney Int. 2003 Nov;64(5):1605-19. PubMed PMID: 14531792. 19: Garg TK, Chang JY. Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2. BMC Ophthalmol. 2003 Mar 21;3:5. PubMed PMID: 12659653; PubMed Central PMCID: PMC153521. 20: Bullard LE, Qi X, Penn JS. Role for extracellular signal-responsive kinase-1 and -2 in retinal angiogenesis. Invest Ophthalmol Vis Sci. 2003 Apr;44(4):1722-31. PubMed PMID: 12657614.