Synonym
L 670548; L-670548; L670548; L-670,548; L 670,548; L670,548;
IUPAC/Chemical Name
5-(1-azabicyclo[2.2.1]heptan-3-yl)-3-methyl-1,2,4-oxadiazole
InChi Key
JRYHRRQEXVCFPV-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H13N3O/c1-6-10-9(13-11-6)8-5-12-3-2-7(8)4-12/h7-8H,2-5H2,1H3
SMILES Code
CC1=NOC(C2CN3CCC2C3)=N1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
179.22
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Freedman SB, Patel S, Harley EA, Iversen LL, Baker R, Showell GA, Saunders J, McKnight A, Newberry N, Scholey K, et al. L-687,306: a functionally selective and potent muscarinic M1 receptor agonist. Eur J Pharmacol. 1992 Apr 29;215(1):135-6. PubMed PMID: 1516645.
3: Showell GA, Baker R, Davis J, Hargreaves R, Freedman SB, Hoogsteen K, Patel S, Snow RJ. Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane. J Med Chem. 1992 Mar 6;35(5):911-6. PubMed PMID: 1548680.
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5: Roberts KE, Newberry NR. A pharmacological study of the responses induced by muscarinic agonists on the isolated superior cervical ganglion of the guinea-pig. Eur J Pharmacol. 1990 Sep 21;186(2-3):257-65. PubMed PMID: 2289527.
