L 662583 | CAS#119731-75-8 | carbonic anhydrase inhibitor

MedKoo Cat#: 596615 | Name: L 662583

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L 662583 is a topical carbonic anhydrase inhibitor.

Chemical Structure

L 662583

CAS#119731-75-8

Theoretical Analysis

MedKoo Cat#: 596615

Name: L 662583

CAS#: 119731-75-8

Chemical Formula: C13H17ClN2O5S3

Exact Mass:

Molecular Weight: 412.91

Elemental Analysis: C, 37.81; H, 4.15; Cl, 8.59; N, 6.78; O, 19.37; S, 23.29

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

L-662,583; L 662,583; L662,583; L 662583; L-662583; L662583;

IUPAC/Chemical Name

5-((3-((dimethylamino)methyl)-4-hydroxyphenyl)sulfonyl)thiophene-2-sulfonamide hydrochloride

InChi Key

BFZQSMDOPQCKCT-UHFFFAOYSA-N

InChi Code

InChI=1S/C13H16N2O5S3.ClH/c1-15(2)8-9-7-10(3-4-11(9)16)22(17,18)12-5-6-13(21-12)23(14,19)20;/h3-7,16H,8H2,1-2H3,(H2,14,19,20);1H

SMILES Code

O=S(C1=CC=C(S(=O)(C2=CC=C(O)C(CN(C)C)=C2)=O)S1)(N)=O.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 412.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Brechue WF, Maren TH. pH and drug ionization affects ocular pressure lowering of topical carbonic anhydrase inhibitors. Invest Ophthalmol Vis Sci. 1993 Jul;34(8):2581-7. PubMed PMID: 8325759. 2: Sugrue MF, Gautheron P, Mallorga P, Nolan TE, Graham SL, Schwam H, Shepard KL, Smith RL. L-662,583 is a topically effective ocular hypotensive carbonic anhydrase inhibitor in experimental animals. Br J Pharmacol. 1990 Jan;99(1):59-64. PubMed PMID: 2110013; PubMed Central PMCID: PMC1917492.