Synonym
L 652117; L-652117; L652117; L 652,306; L-652,306; L652,306;
IUPAC/Chemical Name
ethyl (2S,3R)-3-ethyl-1-((4-nitrophenyl)sulfonyl)-4-oxoazetidine-2-carboxylate
InChi Key
FYFRVXKQSCCYAE-NEPJUHHUSA-N
InChi Code
InChI=1S/C14H16N2O7S/c1-3-11-12(14(18)23-4-2)15(13(11)17)24(21,22)10-7-5-9(6-8-10)16(19)20/h5-8,11-12H,3-4H2,1-2H3/t11-,12+/m1/s1
SMILES Code
O=C([C@H]([C@H]1CC)N(S(=O)(C2=CC=C([N+]([O-])=O)C=C2)=O)C1=O)OCC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
356.34
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Wilmouth RC, Westwood NJ, Anderson K, Brownlee W, Claridge TD, Clifton IJ, Pritchard GJ, Aplin RT, Schofield CJ. Inhibition of elastase by N-sulfonylaryl beta-lactams: anatomy of a stable acyl-enzyme complex. Biochemistry. 1998 Dec 15;37(50):17506-13. PubMed PMID: 9860865.
2: Knight WB, Swiderek KM, Sakuma T, Calaycay J, Shively JE, Lee TD, Covey TR, Shushan B, Green BG, Chabin R, et al. Electrospray ionization mass spectrometry as a mechanistic tool: mass of human leucocyte elastase and a beta-lactam-derived E-I complex. Biochemistry. 1993 Mar 2;32(8):2031-5. PubMed PMID: 8095408.
3: Knight WB, Chabin R, Green B. Inhibition of human serine proteases by substituted 2-azetidinones. Arch Biochem Biophys. 1992 Aug 1;296(2):704-8. PubMed PMID: 1632655.
