L 656224 | CAS#102612-16-8 | 5-LO inhibitor

MedKoo Cat#: 596598 | Name: L 656224

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L 656224 is a 5-LO inhibitor.

Chemical Structure

L 656224

CAS#102612-16-8

Theoretical Analysis

MedKoo Cat#: 596598

Name: L 656224

CAS#: 102612-16-8

Chemical Formula: C20H21ClO3

Exact Mass: 344.1179

Molecular Weight: 344.83

Elemental Analysis: C, 69.66; H, 6.14; Cl, 10.28; O, 13.92

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

L 656224; L 656224; L 656224; L-656,224; L 656,224; L656,224;

IUPAC/Chemical Name

7-chloro-2-(4-methoxybenzyl)-3-methyl-5-propylbenzofuran-4-ol

InChi Key

PLRQEJPVGOQVSJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H21ClO3/c1-4-5-14-11-16(21)20-18(19(14)22)12(2)17(24-20)10-13-6-8-15(23-3)9-7-13/h6-9,11,22H,4-5,10H2,1-3H3

SMILES Code

OC1=C2C(C)=C(CC3=CC=C(OC)C=C3)OC2=C(Cl)C=C1CCC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 344.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Gyömber E, Vattay P, Szabo S, Rainsford KD. Effect of lipoxygenase inhibitors and leukotriene antagonists on acute and chronic gastric haemorrhagic mucosal lesions in ulcer models in the rat. J Gastroenterol Hepatol. 1996 Oct;11(10):922-7. PubMed PMID: 8912128. 2: Shraga-Levine Z, Ben-Menahem D, Naor Z. Arachidonic acid and lipoxygenase products stimulate protein kinase C beta mRNA levels in pituitary alpha T3-1 cell line: role in gonadotropin-releasing hormone action. Biochem J. 1996 Jun 1;316 ( Pt 2):667-70. PubMed PMID: 8687415; PubMed Central PMCID: PMC1217399. 3: Rainsford KD, Ying C, Smith F. Effects of 5-lipoxygenase inhibitors on interleukin production by human synovial tissues in organ culture: comparison with interleukin-1-synthesis inhibitors. J Pharm Pharmacol. 1996 Jan;48(1):46-52. PubMed PMID: 8722494. 4: Rainsford KD, Ying C, Smith F. Selective effects of some 5-lipoxygenase inhibitors on synovial interleukin-1 (IL-1) production compared with IL-1 synthesis inhibitors. Agents Actions. 1993;39 Spec No:C186-8. PubMed PMID: 8273563. 5: Wise LD, Vetter CM, Anderson CA, Antonello JM, Clark RL. Reversible effects of triamcinolone and lack of effects with aspirin or L-656,224 on external genitalia of male Sprague-Dawley rats exposed in utero. Teratology. 1991 Nov;44(5):507-20. PubMed PMID: 1771593. 6: Rouzer CA, Riendeau D, Falgueyret JP, Lau CK, Gresser MJ. Inhibition of human leukocyte 5-lipoxygenase by a 4-hydroxybenzofuran, L-656,224. Evidence for enzyme reduction and inhibitor degradation. Biochem Pharmacol. 1991 May 1;41(9):1365-73. PubMed PMID: 2018568. 7: Lau CK, Bélanger PC, Scheigetz J, Dufresne C, Williams HW, Maycock AL, Guindon Y, Bach T, Dallob AL, Denis D, et al. Synthesis and structure-activity relationships of a novel class of 5-lipoxygenase inhibitors. 2-(Phenylmethyl)-4-hydroxy-3,5-dialkylbenzofurans: the development of L-656,224. J Med Chem. 1989 Jun;32(6):1190-7. PubMed PMID: 2542553. 8: Belanger P, Maycock A, Guindon Y, Bach T, Dollob AL, Dufresne C, Ford-Hutchinson AW, Gale PH, Hopple S, Lau CK, et al. L-656,224 (7-chloro-2-[(4-methoxyphenyl)methyl]-3- methyl-5-propyl-4-benzofuranol): a novel, selective, orally active 5-lipoxygenase inhibitor. Can J Physiol Pharmacol. 1987 Dec;65(12):2441-8. PubMed PMID: 2835137.