MedKoo Cat#: 559095 | Name: L-649923

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L-649923 is a bioactive chemical.

Chemical Structure

L-649923
L-649923
CAS#114370-57-9

Theoretical Analysis

MedKoo Cat#: 559095

Name: L-649923

CAS#: 114370-57-9

Chemical Formula: C25H31NaO6S

Exact Mass: 482.1739

Molecular Weight: 482.56

Elemental Analysis: C, 62.22; H, 6.48; Na, 4.76; O, 19.89; S, 6.64

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
L-649923; L 649923; L649923;
IUPAC/Chemical Name
sodium rel-(3R,4S)-4-(4-((3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl)thio)phenyl)-4-hydroxy-3-methylbutanoate
InChi Key
HYMFDMFIXDCBBD-AUALFVNHSA-M
InChi Code
InChI=1S/C25H32O6S.Na/c1-4-6-21-22(12-11-20(17(3)26)25(21)30)31-13-5-14-32-19-9-7-18(8-10-19)24(29)16(2)15-23(27)28;/h7-12,16,24,29-30H,4-6,13-15H2,1-3H3,(H,27,28);/q;+1/p-1/t16-,24+;/m1./s1
SMILES Code
O=C([O-])C[C@@H](C)[C@H](O)C1=CC=C(SCCCOC2=CC=C(C(C)=O)C(O)=C2CCC)C=C1.[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 482.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gyömber E, Vattay P, Szabo S, Rainsford KD. Effect of lipoxygenase inhibitors and leukotriene antagonists on acute and chronic gastric haemorrhagic mucosal lesions in ulcer models in the rat. J Gastroenterol Hepatol. 1996 Oct;11(10):922-7. PubMed PMID: 8912128. 2: Jorgensen NK, Lambert IH, Hoffmann EK. Role of LTD4 in the regulatory volume decrease response in Ehrlich ascites tumor cells. J Membr Biol. 1996 May;151(2):159-73. PubMed PMID: 8661498. 3: Cicala C, Cirino G. Phospholipase A2-induced hypotension in the rat and its pharmacological modulation. Gen Pharmacol. 1993 Sep;24(5):1197-202. PubMed PMID: 8270179. 4: Leikauf GD. Mechanisms of aldehyde-induced bronchial reactivity: role of airway epithelium. Res Rep Health Eff Inst. 1992 Feb;(49):1-35. PubMed PMID: 1315139. 5: Hu WM, Man RY. Interaction of vasoactive substances released by platelet-activating factor in the rat perfused heart. Br J Pharmacol. 1991 Dec;104(4):933-7. PubMed PMID: 1810604; PubMed Central PMCID: PMC1908832. 6: Perico N, Pasini M, Gaspari F, Abbate M, Remuzzi G. Co-participation of thromboxane A2 and leukotriene C4 and D4 in mediating cyclosporine-induced acute renal failure. Transplantation. 1991 Nov;52(5):873-8. PubMed PMID: 1835198. 7: Perico N, Cornejo RP, Benigni A, Malanchini B, Ladny JR, Remuzzi G. Endothelin induces diuresis and natriuresis in the rat by acting on proximal tubular cells through a mechanism mediated by lipoxygenase products. J Am Soc Nephrol. 1991 Jul;2(1):57-69. PubMed PMID: 1655094. 8: Hu W, Kinnaird AA, Man RY. Mechanisms of the coronary vascular effects of platelet-activating factor in the rat perfused heart. Br J Pharmacol. 1991 May;103(1):1097-102. PubMed PMID: 1652337; PubMed Central PMCID: PMC1908074. 9: Chiono M, Heller RS, Andazola JJ, Herman CA. Leukotriene C4 binds to receptors and has positive inotropic effects in bullfrog heart. J Pharmacol Exp Ther. 1991 Mar;256(3):1042-8. PubMed PMID: 2005570. 10: Cicala C, Sorrentino R, Sorrentino L, Cirino G. Effect of L-649, 923, an LTD4 antagonist, on phospholipase A2-induced hypotension. Pharmacol Res. 1990 Sep-Oct;22 Suppl 3:83. PubMed PMID: 2097660. 11: Wallace JL, McKnight GW, Keenan CM, Byles NI, MacNaughton WK. Effects of leukotrienes on susceptibility of the rat stomach to damage and investigation of the mechanism of action. Gastroenterology. 1990 May;98(5 Pt 1):1178-86. PubMed PMID: 2157619. 12: Flowers BK, Proud D, Kagey-Sobotka A, Lichtenstein LM, Naclerio RM. The effect of a leukotriene antagonist on the early response to antigen. Otolaryngol Head Neck Surg. 1990 Mar;102(3):219-24. PubMed PMID: 2108408. 13: Fraser DG, Regal JF. C5a/C5ades-Arg-induced increase in blood pressure in the guinea pig: role of thromboxane. Immunopharmacology. 1990 Jan-Feb;19(1):59-68. PubMed PMID: 1968450. 14: Cirino G, Peers SH, Wallace JL, Flower RJ. A study of phospholipase A2-induced oedema in rat paw. Eur J Pharmacol. 1989 Aug 3;166(3):505-10. PubMed PMID: 2806373. 15: Leikauf GD, Doupnik CA, Leming LM, Wey HE. Sulfidopeptide leukotrienes mediate acrolein-induced bronchial hyperresponsiveness. J Appl Physiol (1985). 1989 Apr;66(4):1838-45. PubMed PMID: 2543658. 16: Cassin S, Gause G, Davis T, ter Riet M, Baker R. Do inhibitors of lipoxygenase and cyclooxygenase block neonatal hypoxic pulmonary vasoconstriction? J Appl Physiol (1985). 1989 Apr;66(4):1779-84. PubMed PMID: 2499569. 17: Sirén AL, Eimerl J, Feuerstein G. L-649,923: an antagonist of cardiac and vascular leukotriene D4 receptors. J Cardiovasc Pharmacol. 1989 Feb;13(2):210-7. PubMed PMID: 2468948. 18: Knutson L, Nimbratt C, Flemström G. Effects of leukotriene D4, the antagonist L-649-923, and arachidonic acid on duodenal bicarbonate secretion in the rat in vivo. Scand J Gastroenterol. 1988 Dec;23(10):1225-31. PubMed PMID: 3249920. 19: Del Monte M, Subissi A. Platelet-activating factor-induced contraction of guinea-pig lung parenchymal strips: possible involvement of arachidonate metabolites. Naunyn Schmiedebergs Arch Pharmacol. 1988 Oct;338(4):417-21. PubMed PMID: 3149718. 20: Jacques CA, Spur BW, Crea AE, Lee TH. The contractile activities of lipoxin A4 and lipoxin B4 for guinea-pig airway tissues. Br J Pharmacol. 1988 Oct;95(2):562-8. PubMed PMID: 2852525; PubMed Central PMCID: PMC1854178.