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MedKoo Cat#: 596586 | Name: L 648051

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L 648051 is an antagonist of leukotriene D4 receptor.

Chemical Structure

L 648051
L 648051
CAS#91541-18-3

Theoretical Analysis

MedKoo Cat#: 596586

Name: L 648051

CAS#: 91541-18-3

Chemical Formula: C24H28O8S

Exact Mass: 476.1505

Molecular Weight: 476.54

Elemental Analysis: C, 60.49; H, 5.92; O, 26.86; S, 6.73

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
L 648051; L48051; L-648051; 4-Apsob;
IUPAC/Chemical Name
4-(4-((3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl)sulfonyl)phenyl)-4-oxobutanoic acid
InChi Key
ZAKKEARLDPTRLX-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H28O8S/c1-3-5-20-22(12-10-19(16(2)25)24(20)29)32-14-4-15-33(30,31)18-8-6-17(7-9-18)21(26)11-13-23(27)28/h6-10,12,29H,3-5,11,13-15H2,1-2H3,(H,27,28)
SMILES Code
O=C(O)CCC(C1=CC=C(S(=O)(CCCOC2=CC=C(C(C)=O)C(O)=C2CCC)=O)C=C1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 476.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gök S, Ulker S, Evinç A. Possible contribution of leukotrienes in the arrhythmogenic effects of digoxin on isolated guinea-pig hearts. Pharmacology. 1998 Nov;57(5):279-84. PubMed PMID: 9742293. 2: Gök S, Banoaglu N. Effects of a leukotriene D4 receptor antagonist, L-648,051, and a dual inhibitor lypoxygenase and cyclooxygenase, BW-755C, on digoxin-induced arrhythmias in guinea-pigs. Arch Int Pharmacodyn Ther. 1993 Jan-Feb;321:72-80. PubMed PMID: 8391788. 3: Rasmussen JB, Eriksson LO, Tagari P, Margolskee DJ, Girard Y, Andersson KE. Urinary LTE4 excretion in antigen-provoked asthmatic patients treated with the inhaled LTD4 antagonist, L-648,051. Allergy. 1992 Dec;47(6):599-603. PubMed PMID: 1337423. 4: Rasmussen JB, Eriksson LO, Tagari P, Stahl EG, Andersson KE. Reduced nonspecific bronchial reactivity and decreased airway response to antigen challenge in atopic asthmatic patients treated with the inhaled leukotriene D4 antagonist, L-648,051. Allergy. 1992 Dec;47(6):604-9. PubMed PMID: 1285568. 5: Miura T, Inagaki N, Goto S, Yoshida K, Nagai H, Koda A. Leukotriene receptors in the skin of rats differ from those of mouse skin or rat stomach strip. Eur J Pharmacol. 1992 Oct 20;221(2-3):333-42. PubMed PMID: 1330627. 6: Lindén A, Löfdahl CG, Ullman A, Skoogh BE. In vitro characteristics of spontaneous airway tone in the guinea-pig. Acta Physiol Scand. 1991 Jul;142(3):351-7. PubMed PMID: 1656702. 7: Rasmussen JB, Eriksson LO, Andersson KE. Reversal and prevention of airway response to antigen challenge by the inhaled leukotriene D4 antagonist (L-648,051) in patients with atopic asthma. Allergy. 1991 May;46(4):266-73. PubMed PMID: 1897688. 8: Bel EH, Timmers MC, Dijkman JH, Stahl EG, Sterk PJ. The effect of an inhaled leukotriene antagonist, L-648,051, on early and late asthmatic reactions and subsequent increase in airway responsiveness in man. J Allergy Clin Immunol. 1990 Jun;85(6):1067-75. PubMed PMID: 2191993. 9: Evans JM, Barnes NC, Zakrzewski JT, Sciberras DG, Stahl EG, Piper PJ, Costello JF. L-648,051, a novel cysteinyl-leukotriene antagonist is active by the inhaled route in man. Br J Clin Pharmacol. 1989 Aug;28(2):125-35. PubMed PMID: 2775617; PubMed Central PMCID: PMC1379893. 10: Thomas HM 3rd, Sourour MS, Lopez D, Foster SH. Antagonism of leukotriene receptors and administration of a 5-lipoxygenase inhibitor do not affect hypoxic vasoconstriction. Lung. 1989;167(3):187-98. PubMed PMID: 2567790. 11: Björck T, Dahlén SE. Evidence indicating that leukotrienes C4, D4 and E4 are major mediators of contraction induced by anti-IgE in human bronchi. Agents Actions. 1989 Jan;26(1-2):87-9. PubMed PMID: 2540649. 12: Tocco DJ, Duncan AE, deLuna FA, Wells G. The physiological disposition of aerosolized 4-[(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl)sulfonyl]-gamma -oxobenzenebutanoate (L-648,051) in rats. Drug Metab Dispos. 1988 Sep-Oct;16(5):697-700. PubMed PMID: 2906592. 13: Tocco DJ, deLuna FA, Duncan AE, Ramjit HG, Pitzenberger SM, Hsieh JY. Disposition and metabolism of sodium 4-[(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl)sulfonyl]-gamma -oxobenzenebutanoate in rats and dogs. Drug Metab Dispos. 1988 Sep-Oct;16(5):690-6. PubMed PMID: 2906591. 14: Jones TR, Charette L, Denis D. Leukotriene and anti-IgE induced contractions of human isolated trachea: studies with leukotriene receptor antagonists and a novel 5-lipoxygenase inhibitor. Can J Physiol Pharmacol. 1988 Jun;66(6):762-8. PubMed PMID: 2844372. 15: Young RN. L-648,051, a potent and specific aerosol active leukotriene D4 antagonist. Agents Actions Suppl. 1988;23:113-9. PubMed PMID: 2845747. 16: Barnes N, Evans J, Zakrzewski J, Piper P, Costello J. Studies of leukotriene antagonists and synthesis inhibitors in man. Prog Clin Biol Res. 1988;263:393-403. Review. PubMed PMID: 2837778. 17: Biollaz J, Stahl E, Hsieh JY, Distlerath L, Jaeger A, Leuenberger P, Schelling JL. Tolerability and pharmacokinetics of L-648,051. A leukotriene D4-receptor antagonist, in healthy volunteers. Eur J Clin Pharmacol. 1988;33(6):603-7. PubMed PMID: 2835245. 18: Rothwell CM, Hsieh JY, Bayne WF. High-performance liquid chromatographic determination of 4-[(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl)sulfonyl]-gamma -oxobenzenebutanoic acid and metabolites in human plasma. J Chromatogr. 1987 Jul 3;417(2):447-51. PubMed PMID: 2821046. 19: Garceau D, Ford-Hutchinson AW. The role of leukotriene D4 as a mediator of allergic conjunctivitis in the guinea-pig. Eur J Pharmacol. 1987 Feb 24;134(3):285-92. PubMed PMID: 3569415. 20: Young RN, Jones TR, Atkinson JG, Bélanger P, Champion E, Denis D, DeHaven RN, Ford-Hutchinson AW, Fortin R, Frenette R, et al. Novel arylthio- and arylsulfonylpropyloxyacetophenones: design and synthesis of L-648,051 and L-649,923, potent antagonists of leukotriene D4. Adv Prostaglandin Thromboxane Leukot Res. 1987;17A:544-8. PubMed PMID: 2959111.