MedKoo Cat#: 555261 | Name: TCS-2002
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TCS-2002 is a Potent inhibitor of GSK-3β (IC50 = 35 nM). Oral adminstration inhibits cold water stress-induced tau hyperphosphorylation in the mouse brain.

Chemical Structure

TCS-2002
TCS-2002
CAS#1005201-24-0

Theoretical Analysis

MedKoo Cat#: 555261

Name: TCS-2002

CAS#: 1005201-24-0

Chemical Formula: C18H14N2O3S

Exact Mass: 338.0725

Molecular Weight: 338.38

Elemental Analysis: C, 63.89; H, 4.17; N, 8.28; O, 14.18; S, 9.47

Price and Availability

Size Price Availability Quantity
10mg USD 500.00
25mg USD 1,300.00 2 Weeks
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Related CAS #
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Synonym
TCS-2002; TCS 2002; TCS2002.
IUPAC/Chemical Name
2-Methyl-5-[3-[4-(methylsulfinyl)phenyl]-5-benzofuranyl]-1,3,4-oxadiazole
InChi Key
RCKYSTKYIVULEK-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H14N2O3S/c1-11-19-20-18(23-11)13-5-8-17-15(9-13)16(10-22-17)12-3-6-14(7-4-12)24(2)21/h3-10H,1-2H3
SMILES Code
O=S(C1=CC=C(C2=COC3=CC=C(C4=NN=C(C)O4)C=C23)C=C1)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 338.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Saitoh et al (2009) 2-{3-[4-(alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3β with good brain permeability. J.Med.Chem. 52 6270 PMID: 19775160