L 645164 | CAS#85493-98-7 | hydroxymethylglutaryl-CoA reductase inhibitor

MedKoo Cat#: 596580 | Name: L 645164

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L 645164 is a hydroxymethylglutaryl-CoA reductase inhibitor.

Chemical Structure

L 645164

CAS#85493-98-7

Theoretical Analysis

MedKoo Cat#: 596580

Name: L 645164

CAS#: 85493-98-7

Chemical Formula: C22H23FO3

Exact Mass: 354.1631

Molecular Weight: 354.42

Elemental Analysis: C, 74.56; H, 6.54; F, 5.36; O, 13.54

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

L 645164; L-645164; L645164;

IUPAC/Chemical Name

(4R,6S)-6-((E)-2-(4'-fluoro-3,3',5-trimethyl-[1,1'-biphenyl]-2-yl)vinyl)-4-hydroxytetrahydro-2H-pyran-2-one

InChi Key

BNIBDNOALUGLCI-PJHKVULZSA-N

InChi Code

InChI=1S/C22H23FO3/c1-13-8-14(2)19(6-5-18-11-17(24)12-22(25)26-18)20(9-13)16-4-7-21(23)15(3)10-16/h4-10,17-18,24H,11-12H2,1-3H3/b6-5+/t17-,18-/m1/s1

SMILES Code

O=C1C[C@H](O)C[C@@H](/C=C/C2=C(C)C=C(C)C=C2C3=CC=C(F)C(C)=C3)O1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 354.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Gerson RJ, Allen HL, Lankas GR, MacDonald JS, Alberts AW, Bokelman DL. The toxicity of a fluorinated-biphenyl HMG-CoA reductase inhibitor in beagle dogs. Fundam Appl Toxicol. 1991 Feb;16(2):320-9. PubMed PMID: 2055362. 2: Gerson RJ, MacDonald JS, Alberts AW, Chen J, Yudkovitz JB, Greenspan MD, Rubin LF, Bokelman DL. On the etiology of subcapsular lenticular opacities produced in dogs receiving HMG-CoA reductase inhibitors. Exp Eye Res. 1990 Jan;50(1):65-78. PubMed PMID: 2307197.