MedKoo Cat#: 591320 | Name: Apholate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Apholate is a chemical used in pesticides that inhibits the organism's reproduction.

Chemical Structure

Apholate
Apholate
CAS#52-46-0

Theoretical Analysis

MedKoo Cat#: 591320

Name: Apholate

CAS#: 52-46-0

Chemical Formula: C12H24N9P3

Exact Mass: 387.1368

Molecular Weight: 387.31

Elemental Analysis: C, 37.21; H, 6.25; N, 32.55; P, 23.99

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Pholate; Apholate; AI3-26316; AI326316; AI3 26316;
IUPAC/Chemical Name
1,3,5,2,4,6-Triazatriphosphorine, 2,2,4,4,6,6-hexakis(1-aziridiny l)-2,2,4,4,6,6-hexahydro-
InChi Key
PXZAWHSJYIECNQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H24N9P3/c1-2-16(1)22(17-3-4-17)13-23(18-5-6-18,19-7-8-19)15-24(14-22,20-9-10-20)21-11-12-21/h1-12H2
SMILES Code
N1(P2(N3CC3)=NP(N4CC4)(N5CC5)=NP(N6CC6)(N7CC7)=N2)CC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 387.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Haqqi TM. Sister-chromatid exchanges and chromosomal aberrations in lymphocytes of male albino rats treated with an alkylating agent, apholate (NSC 26, 812; ENT 26, 316). Mutat Res. 1984 Nov-Dec;141(3-4):175-81. PubMed PMID: 6239979. 2: Haqqi TM, Adhami UM. Testicular damage and change in serum LDH isozyme pattern induced by multiple sub-lethal doses of apholate in albino rats. Toxicol Lett. 1982 Jul;12(2-3):199-205. PubMed PMID: 6214049. 3: Mittal PK, Sheikher C, Nath V. Cytochemical changes induced by apholate, tepa and hempa during vitellogenesis in Locusta migratoria. Cytobios. 1980;28(111-112):161-4. PubMed PMID: 6163593. 4: Haqqi TM, Adhami UM. Effect of apholate (ENT 26316; NSC 26812) on nucleic acids, total protein content & activity levels of aminotransferases (GOT, GPT), alkaline phosphatase & 5'-nucleotidase in liver of male albino rats. Indian J Exp Biol. 1979 May;17(5):488-92. PubMed PMID: 230151. 5: Taneja SK, Sood V, Taneja S, Nath A. Effect of apholate on neurosecretion of pars intercerebralis, fat bodies & ovarian development of the red cotton bug Dysdercus koenigii (F). Indian J Exp Biol. 1979 Feb;17(2):133-8. PubMed PMID: 157974. 6: Haqqi TM, Adhami UM. Effect of apholate (NSC 26812; ENT 26316) on the nucleic acids & protein content in the spleen of male albino rats. Indian J Exp Biol. 1978 Jun;16(6):720-2. PubMed PMID: 151666. 7: Labrecque GC, Fye RL. Cytogenetic and other effects of the chemosterilants tepa, metepa, apholate an hempa in insects (a review). Mutat Res. 1978;47(2):99-113. Review. PubMed PMID: 75501. 8: Berndt VK, Nitschmann J. [Queens' technic in Pharaoh's ant control. 2. Synergistic effects]. Angew Parasitol. 1976 Sep;17(3):141-6. German. PubMed PMID: 62525. 9: Saxena SC, Aditya V. Histopathology and histochemistry of insects treated with chemosterilants: IX. Tumor like growth in the ovary of Periplaneta americana (L) treated with apholate. Bull Environ Contam Toxicol. 1976 Apr;15(4):485-7. PubMed PMID: 130950. 10: Apholate. IARC Monogr Eval Carcinog Risk Chem Man. 1975;9:31-6. Review. PubMed PMID: 136416. 11: Mathew G, Rai KS. Chemosterilant (apholate)-induced ultrastructural changes during oogenesis in Aedes aegypti. Cytobios. 1975;12(45):45-56. PubMed PMID: 126140. 12: Manna GK, Das PK. Effect of two chemosterilants apholate and hempa on the bone-marrow chromosomes of mice. Can J Genet Cytol. 1973 Sep;15(3):451-9. PubMed PMID: 4271647. 13: Morgan PB. House flies: effect of apholate and its failure to induce resistance. J Econ Entomol. 1973 Jun;66(3):609-11. PubMed PMID: 4268032. 14: Saxena SC, Vikramaditya. Histopathology and histochemistry of the insects treated with chemosterilants. IV-on the seminal vesicles and accessory glands of Poicelocerus pictus treated with apholate and tepa. Bull Environ Contam Toxicol. 1973 Apr;9(4):218-21. PubMed PMID: 4131087. 15: Seawright JA. A genetic study of apholate resistance in Aedes aegypti. J Econ Entomol. 1972 Oct;65(5):1357-61. PubMed PMID: 4263864. 16: Painter RR, Kilgore WW, Gadallah AI. Influence of apholate on the haemolymph proteins of adult house flies. J Econ Entomol. 1972 Feb;65(1):23-7. PubMed PMID: 4257784. 17: Hafez M, Aboul-Nasr AE, Salama HS. Studies on the control of mosquitoes in Egypt by means of chemosterilants. IV. Sterilization of Anopheles pharoensis and Culex pipiens by apholate and thiotepa. J Econ Entomol. 1971 Jun;64(3):675-8. PubMed PMID: 5004301. 18: Grover KK, Pillai MK, Dass CM. Cytogenetic basis of chemically induced sterility in Culex pipiens fatigans Wiedemann. 3. Effect of apholate & hempa on DNA synthesis in the gonads. Indian J Exp Biol. 1971 Apr;9(2):150-2. PubMed PMID: 5092724. 19: Bransby-Williams WR. A field release of male Culex pipiens fatigans sterilised by apholate. East Afr Med J. 1971 Feb;48(2):68-75. PubMed PMID: 5088514. 20: Hafez M, Osman MF, Erakey MA. Studies on control of house flies in Egypt by chemosterilants. 3. Sterilization of Musca sorbens by apholate, tepa, and hempa. J Econ Entomol. 1970 Aug;63(4):1167-9. PubMed PMID: 5475198.