Dimethoate | CAS#60-51-5 | organothiophosphorus cholinesterase inhibitor

MedKoo Cat#: 596541 | Name: Dimethoate

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dimethoate is an organothiophosphorus cholinesterase inhibitor that is used as a systemic and contact insecticide.

Chemical Structure

Dimethoate

CAS#60-51-5

Theoretical Analysis

MedKoo Cat#: 596541

Name: Dimethoate

CAS#: 60-51-5

Chemical Formula: C5H12NO3PS2

Exact Mass: 228.9996

Molecular Weight: 229.25

Elemental Analysis: C, 26.20; H, 5.28; N, 6.11; O, 20.94; P, 13.51; S, 27.97

Price and Availability

Size	Price	Availability	Quantity
100mg	USD 350.00	2 Weeks
1g	USD 950.00	2 Weeks

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Related CAS #

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Synonym

Dimethoate; Lurgo; L-395; L 395; L395; Phosphamid; Rogor;

IUPAC/Chemical Name

O,O-dimethyl S-(2-(methylamino)-2-oxoethyl) phosphorodithioate

InChi Key

MCWXGJITAZMZEV-UHFFFAOYSA-N

InChi Code

InChI=1S/C5H12NO3PS2/c1-6-5(7)4-12-10(11,8-2)9-3/h4H2,1-3H3,(H,6,7)

SMILES Code

O=C(NC)CSP(OC)(OC)=S

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Dimethoate is an effective systemic insecticide for use on plants, has shown promise as a chemotherapeutic agent for control of cattle grubs and certain other insect pests of farm animals, and has high contact toxicity to house-flies and many other insects.

In vitro activity:

Dimethoate caused a significant induction of oxidative damage in spermatozoa at different concentrations as evidenced by increased MDA levels. However, a significant decrease in sperm mobility, viability and activities SOD, CAT and GPx was observed. Vitamins pre-treated spermatozoa showed a significant protection against the cytotoxic effects induced by dimethoate on studied parameters. Reference: Andrologia. 2012 May;44 Suppl 1:272-9. https://pubmed.ncbi.nlm.nih.gov/21806655/

In vivo activity:

The results showed that DM (dimethoate)significantly affected sperm quality a decrease in sperm motility and an increase in abnormal sperm morphology and caused marked alterations in the microstructures of testicular tissues. When treated males were mated with untreated females, a decline in the number of live embryos was found, while the green tea extract revealed an effective role by reducing those negative influences. Reference: Open Vet J. 2022 Mar-Apr;12(2):165-170. https://pubmed.ncbi.nlm.nih.gov/35603062/

	Solvent	mg/mL	mM	comments
Solubility
	Water	10.4	45.45

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 229.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Jiang Q, Qi X, Ding C, Liu X, Lei Y, Li S, Cao Z. Melatonin Rescues Dimethoate Exposure-Induced Meiotic and Developmental Defects of Porcine Oocytes. Animals (Basel). 2022 Mar 25;12(7):832. doi: 10.3390/ani12070832. PMID: 35405822; PMCID: PMC8997005. 2. Ben Abdallah F, Fetoui H, Zribi N, Fakfakh F, Ammar-Keskes L. Antioxidant supplementations in vitro improve rat sperm parameters and enhance antioxidant enzyme activities against dimethoate-induced sperm damages. Andrologia. 2012 May;44 Suppl 1:272-9. doi: 10.1111/j.1439-0272.2011.01177.x. Epub 2011 Aug 2. PMID: 21806655. 3. Nazam N, Lone MI, Hamid A, Qadah T, Banjar A, Alam Q, Saeed M, Ahmad W. Dimethoate Induces DNA Damage and Mitochondrial Dysfunction Triggering Apoptosis in Rat Bone-Marrow and Peripheral Blood Cells. Toxics. 2020 Oct 1;8(4):80. doi: 10.3390/toxics8040080. PMID: 33019668; PMCID: PMC7712428. 4. Sasi SM, Alghoul NM, Awayn N, Elghoul A. Positive effect of green tea extract on reproductive toxicity induced by dimethoate in male mice. Open Vet J. 2022 Mar-Apr;12(2):165-170. doi: 10.5455/OVJ.2022.v12.i2.2. Epub 2022 Mar 3. PMID: 35603062; PMCID: PMC9109838.

In vitro protocol:

In vivo protocol:

1. Nazam N, Lone MI, Hamid A, Qadah T, Banjar A, Alam Q, Saeed M, Ahmad W. Dimethoate Induces DNA Damage and Mitochondrial Dysfunction Triggering Apoptosis in Rat Bone-Marrow and Peripheral Blood Cells. Toxics. 2020 Oct 1;8(4):80. doi: 10.3390/toxics8040080. PMID: 33019668; PMCID: PMC7712428. 2. Sasi SM, Alghoul NM, Awayn N, Elghoul A. Positive effect of green tea extract on reproductive toxicity induced by dimethoate in male mice. Open Vet J. 2022 Mar-Apr;12(2):165-170. doi: 10.5455/OVJ.2022.v12.i2.2. Epub 2022 Mar 3. PMID: 35603062; PMCID: PMC9109838.

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