L 368935 | CAS#145878-31-5 | cholecystokinin receptor antagonist

MedKoo Cat#: 596537 | Name: L 368935

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L 368935 is a cholecystokinin receptor antagonist.

Chemical Structure

L 368935

CAS#145878-31-5

Theoretical Analysis

MedKoo Cat#: 596537

Name: L 368935

CAS#: 145878-31-5

Chemical Formula: C27H26N8O2

Exact Mass: 494.2179

Molecular Weight: 494.55

Elemental Analysis: C, 65.57; H, 5.30; N, 22.66; O, 6.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

L 368935; L-368935; L368935; L-368,935; L 368,935; L368,935;

IUPAC/Chemical Name

(R)-1-(3-(1H-tetrazol-5-yl)phenyl)-3-(1-isobutyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea

InChi Key

WOEBZQREQISGPC-VWLOTQADSA-N

InChi Code

InChI=1S/C27H26N8O2/c1-17(2)16-35-22-14-7-6-13-21(22)23(18-9-4-3-5-10-18)29-25(26(35)36)30-27(37)28-20-12-8-11-19(15-20)24-31-33-34-32-24/h3-15,17,25H,16H2,1-2H3,(H2,28,30,37)(H,31,32,33,34)/t25-/m0/s1

SMILES Code

O=C(NC1=CC=CC(C2=NN=NN2)=C1)N[C@H]3C(N(CC(C)C)C4=CC=CC=C4C(C5=CC=CC=C5)=N3)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 494.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Patel S, Chapman KL, Smith AJ, Heald A, Freedman SB. Use of ex vivo binding to estimate brain penetration and central activity of CCK-B antagonists. Ann N Y Acad Sci. 1994 Mar 23;713:360-3. PubMed PMID: 8185188. 2: Pedersen K, Nielsen FC, Rehfeld JF. Regulation of the human cholecystokinin gene. Ann N Y Acad Sci. 1994 Mar 23;713:321-3. PubMed PMID: 8185176. 3: Patel S, Chapman KL, Heald A, Smith AJ, Freedman SB. Measurement of central nervous system activity of systemically administered CCKB receptor antagonists by ex vivo binding. Eur J Pharmacol. 1994 Mar 3;253(3):237-44. PubMed PMID: 8200418.