Synonym
AFD-21, AFD21, AFD 21, NS-2 Class 1 antiarrhythmic agent
IUPAC/Chemical Name
Benzenemethanol, alpha-(3-(bis-(2-methylpropyl)amino)propyl)-alpha-phenyl-, (Z)-2-butenedioate (1:1) (salt)
InChi Key
FNQOYOWVZPEOOK-BTJKTKAUSA-N
InChi Code
InChI=1S/C24H35NO.C4H4O4/c1-20(2)18-25(19-21(3)4)17-11-16-24(26,22-12-7-5-8-13-22)23-14-9-6-10-15-23;5-3(6)1-2-4(7)8/h5-10,12-15,20-21,26H,11,16-19H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
SMILES Code
OC(C1=CC=CC=C1)(CCCN(CC(C)C)CC(C)C)C2=CC=CC=C2.O=C(O)/C=C\C(O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
469.62
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Williams LK, Forero JF, Popovic ZB, Phelan D, Delgado D, Rakowski H, Wintersperger BJ, Thavendiranathan P. Patterns of CMR measured longitudinal strain and its association with late gadolinium enhancement in patients with cardiac amyloidosis and its mimics. J Cardiovasc Magn Reson. 2017 Aug 7;19(1):61. doi: 10.1186/s12968-017-0376-0. PubMed PMID: 28784140; PubMed Central PMCID: PMC5545847.
2: Komori S, Sawanobori T, Tamura K, Kane KA, Parratt JR. Effects of NS-2, a new class 1 antiarrhythmic agent, and AFD-19, its active metabolite, on ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats: comparison with disopyramide and mexiletine. Jpn J Pharmacol. 1994 Jul;65(3):193-200. PubMed PMID: 7799519.
3: Kodama I, Kamiya K, Kawamura T, Suzuki R, Toyama J. Electrophysiological effects of AFD-21 and AFD-19, new antiarrhythmic compounds on papillary muscles and single ventricular myocytes isolated from guinea-pig hearts. Br J Pharmacol. 1990 Dec;101(4):803-8. PubMed PMID: 2085705; PubMed Central PMCID: PMC1917845.
4: Kojima M, Ban T. Effects of AFD-21, a new class I antiarrhythmic agent, and AFD-19, its active metabolite, on the maximal rate of rise of action potentials in guinea pig papillary muscles: dependence on time, voltage, and action potential duration. J Cardiovasc Pharmacol. 1989 Mar;13(3):483-93. PubMed PMID: 2471896.
