MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 591290 | Name: AF-2785

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AF-2785 inhibits cystic fibrosis transmembrane conductance regulator Cl(-) channels in epididymal epithelial cells.

Chemical Structure

AF-2785
AF-2785
CAS# 252025-48-2

Theoretical Analysis

MedKoo Cat#: 591290

Name: AF-2785

CAS#: 252025-48-2

Chemical Formula: C17H12Cl2N2O2

Exact Mass: 346.0276

Molecular Weight: 347.20

Elemental Analysis: C, 58.81; H, 3.48; Cl, 20.42; N, 8.07; O, 9.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
AF-2785; AF 2785; AF2785;
IUPAC/Chemical Name
2-Propenoic acid, 3-(1-((2,4-dichlorophenyl)methyl)-1H-indazol-3-yl)-
InChi Key
JXBHFVLHFJMKPK-BQYQJAHWSA-N
InChi Code
InChI=1S/C17H12Cl2N2O2/c18-12-6-5-11(14(19)9-12)10-21-16-4-2-1-3-13(16)15(20-21)7-8-17(22)23/h1-9H,10H2,(H,22,23)/b8-7+
SMILES Code
O=C(O)/C=C/C1=NN(CC2=CC=C(Cl)C=C2Cl)C3=C1C=CC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 347.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gong XD, Linsdell P, Cheung KH, Leung GP, Wong PY. Indazole inhibition of cystic fibrosis transmembrane conductance regulator Cl(-) channels in rat epididymal epithelial cells. Biol Reprod. 2002 Dec;67(6):1888-96. PubMed PMID: 12444067. 2: Cheng CY, Mo My, Grima J, Saso L, Tita B, Mruk D, Silvestrini B. Indazole carboxylic acids in male contraception. Contraception. 2002 Apr;65(4):265-8. Review. PubMed PMID: 12020774. 3: Cheng CY, Silvestrini B, Grima J, Mo MY, Zhu LJ, Johansson E, Saso L, Leone MG, Palmery M, Mruk D. Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis. Biol Reprod. 2001 Aug;65(2):449-61. PubMed PMID: 11466213. 4: Gong XD, Wong PY. Characterization of Lonidamine and AF2785 blockade of the cyclic AMP-activated chloride current in rat epididymal cells. J Membr Biol. 2000 Dec 1;178(3):225-33. PubMed PMID: 11140278. 5: Gong XD, Wong YL, Leung GP, Cheng CY, Silvestrini B, Wong PY. Lonidamine and analogue AF2785 block the cyclic adenosine 3', 5'-monophosphate-activated chloride current and chloride secretion in the rat epididymis. Biol Reprod. 2000 Sep;63(3):833-8. PubMed PMID: 10952928.