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MedKoo Cat#: 591281 | Name: Toxin IIc

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Toxin IIc is a biochemical.

Chemical Structure

Toxin IIc
Toxin IIc
CAS#104420-17-9

Theoretical Analysis

MedKoo Cat#: 591281

Name: Toxin IIc

CAS#: 104420-17-9

Chemical Formula: C17H24O6

Exact Mass: 324.1573

Molecular Weight: 324.37

Elemental Analysis: C, 62.95; H, 7.46; O, 29.59

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Toxin IIc;
IUPAC/Chemical Name
2,4,6-Octatrienoic acid, 8-((2-hydroxy-3-methyl-1-oxopentyl)oxy)-8-(2-methyloxiranyl)-,(2S-(2R*(2E,4E,6E,8S*(2S*,3R*))))-
InChi Key
PXZGUAVTZUPRMI-MWOWDIBMSA-N
InChi Code
InChI=1S/C17H24O6/c1-4-12(2)15(20)16(21)23-13(17(3)11-22-17)9-7-5-6-8-10-14(18)19/h5-10,12-13,15,20H,4,11H2,1-3H3,(H,18,19)/b6-5+,9-7+,10-8+/t12-,13+,15?,17-/m0/s1
SMILES Code
O=C(O)/C=C/C=C/C=C/[C@@H](OC(C(O)[C@@H](C)CC)=O)[C@@]1(C)OC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 324.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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PubMed PMID: 26565800; PubMed Central PMCID: PMC4643920. 4: Vance DJ, Greene CJ, Rong Y, Mandell LM, Connell TD, Mantis NJ. Comparative Adjuvant Effects of Type II Heat-Labile Enterotoxins in Combination with Two Different Candidate Ricin Toxin Vaccine Antigens. Clin Vaccine Immunol. 2015 Dec;22(12):1285-93. doi: 10.1128/CVI.00402-15. Epub 2015 Oct 21. PubMed PMID: 26491037; PubMed Central PMCID: PMC4658585. 5: Shahar E, Gorodetsky R, Aizenshtein E, Lalush L, Pitcovski J. Modulating the innate immune activity in murine tumor microenvironment by a combination of inducer molecules attached to microparticles. Cancer Immunol Immunother. 2015 Sep;64(9):1137-49. doi: 10.1007/s00262-015-1719-z. Epub 2015 Jun 2. PubMed PMID: 26031575. 6: Hu JC, Mathias-Santos C, Greene CJ, King-Lyons ND, Rodrigues JF, Hajishengallis G, Ferreira LC, Connell TD. Intradermal administration of the Type II heat-labile enterotoxins LT-IIb and LT-IIc of enterotoxigenic Escherichia coli enhances humoral and CD8+ T cell immunity to a co-administered antigen. PLoS One. 2014 Dec 23;9(12):e113978. doi: 10.1371/journal.pone.0113978. eCollection 2014. PubMed PMID: 25536061; PubMed Central PMCID: PMC4275187. 7: Bernardoni JL, Sousa LF, Wermelinger LS, Lopes AS, Prezoto BC, Serrano SM, Zingali RB, Moura-da-Silva AM. Functional variability of snake venom metalloproteinases: adaptive advantages in targeting different prey and implications for human envenomation. PLoS One. 2014 Oct 14;9(10):e109651. doi: 10.1371/journal.pone.0109651. eCollection 2014. PubMed PMID: 25313513; PubMed Central PMCID: PMC4196926. 8: Camargo AC, Lafisca A, Cossi MV, Lanna FG, Dias MR, de Arruda Pinto PS, Nero LA. Low occurrence of Listeria monocytogenes on bovine hides and carcasses in Minas Gerais State, Brazil: molecular characterization and antimicrobial resistance. J Food Prot. 2014 Jul;77(7):1148-52. doi: 10.4315/0362-028X.JFP-13-434. PubMed PMID: 24988021. 9: Berenson CS, Nawar HF, Kruzel RL, Mandell LM, Connell TD. Ganglioside-binding specificities of E. coli enterotoxin LT-IIc: Importance of long-chain fatty acyl ceramide. Glycobiology. 2013 Jan;23(1):23-31. doi: 10.1093/glycob/cws123. Epub 2012 Aug 22. PubMed PMID: 22917572; PubMed Central PMCID: PMC3505011. 10: Wu MC, Chen YC, Lin TL, Hsieh PF, Wang JT. Cellobiose-specific phosphotransferase system of Klebsiella pneumoniae and its importance in biofilm formation and virulence. Infect Immun. 2012 Jul;80(7):2464-72. doi: 10.1128/IAI.06247-11. Epub 2012 May 7. PubMed PMID: 22566508; PubMed Central PMCID: PMC3416469. 11: Jobling MG, Holmes RK. Type II heat-labile enterotoxins from 50 diverse Escherichia coli isolates belong almost exclusively to the LT-IIc family and may be prophage encoded. PLoS One. 2012;7(1):e29898. doi: 10.1371/journal.pone.0029898. Epub 2012 Jan 5. PubMed PMID: 22242186; PubMed Central PMCID: PMC3252337. 12: Nawar HF, Greene CJ, Lee CH, Mandell LM, Hajishengallis G, Connell TD. LT-IIc, a new member of the type II heat-labile enterotoxin family, exhibits potent immunomodulatory properties that are different from those induced by LT-IIa or LT-IIb. Vaccine. 2011 Jan 17;29(4):721-7. doi: 10.1016/j.vaccine.2010.11.020. Epub 2010 Nov 21. PubMed PMID: 21095251; PubMed Central PMCID: PMC3035162. 13: Nawar HF, King-Lyons ND, Hu JC, Pasek RC, Connell TD. LT-IIc, a new member of the type II heat-labile enterotoxin family encoded by an Escherichia coli strain obtained from a nonmammalian host. Infect Immun. 2010 Nov;78(11):4705-13. doi: 10.1128/IAI.00730-10. Epub 2010 Aug 16. PubMed PMID: 20713622; PubMed Central PMCID: PMC2976314. 14: Spicker JS, Pedersen HT, Nielsen HB, Brunak S. Analysis of cell death inducing compounds. Arch Toxicol. 2007 Nov;81(11):803-11. Epub 2007 May 15. PubMed PMID: 17503021. 15: Takagi D, Iwabuchi K, Maeda M, Nakamaru Y, Furuta Y, Fukuda S, Van Kaer L, Nishihira J, Onoé K. Natural killer T cells ameliorate antibody-induced arthritis in macrophage migration inhibitory factor transgenic mice. Int J Mol Med. 2006 Nov;18(5):829-36. PubMed PMID: 17016612. 16: Tayama K, Fujita H, Takahashi H, Nagasawa A, Yano N, Yuzawa K, Ogata A. Measuring mouse sperm parameters using a particle counter and sperm quality analyzer: a simple and inexpensive method. Reprod Toxicol. 2006 Jul;22(1):92-101. Epub 2006 Jan 20. PubMed PMID: 16431076. 17: Valentin E, Lambeau G. What can venom phospholipases A(2) tell us about the functional diversity of mammalian secreted phospholipases A(2)? Biochimie. 2000 Sep-Oct;82(9-10):815-31. Review. PubMed PMID: 11086212. 18: Salvini TF, Belluzzo SS, Selistre de Araújo HS, Souza DH. Regeneration and change of muscle fiber types after injury induced by a hemorrhagic fraction isolated from Agkistrodon contortrix laticinctus venom. Toxicon. 2001 May;39(5):641-9. PubMed PMID: 11072042. 19: Ling H, Pannu NS, Boodhoo A, Armstrong GD, Clark CG, Brunton JL, Read RJ. A mutant Shiga-like toxin IIe bound to its receptor Gb(3): structure of a group II Shiga-like toxin with altered binding specificity. Structure. 2000 Mar 15;8(3):253-64. PubMed PMID: 10745005. 20: Ishizaki J, Suzuki N, Higashino K, Yokota Y, Ono T, Kawamoto K, Fujii N, Arita H, Hanasaki K. Cloning and characterization of novel mouse and human secretory phospholipase A(2)s. J Biol Chem. 1999 Aug 27;274(35):24973-9. PubMed PMID: 10455175.