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MedKoo Cat#: 596474 | Name: Histidylprolineamide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Histidylprolineamide is the N-terminal of TRH.

Chemical Structure

Histidylprolineamide
Histidylprolineamide
CAS#33605-69-5

Theoretical Analysis

MedKoo Cat#: 596474

Name: Histidylprolineamide

CAS#: 33605-69-5

Chemical Formula: C11H17N5O2

Exact Mass: 251.1382

Molecular Weight: 251.29

Elemental Analysis: C, 52.58; H, 6.82; N, 27.87; O, 12.73

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Histidylprolineamide; His-pro-amide;
IUPAC/Chemical Name
1-(L-histidyl)pyrrolidine-2-carboxamide
InChi Key
BVQMQRWLLWQCLL-IENPIDJESA-N
InChi Code
InChI=1S/C11H17N5O2/c12-8(4-7-5-14-6-15-7)11(18)16-3-1-2-9(16)10(13)17/h5-6,8-9H,1-4,12H2,(H2,13,17)(H,14,15)/t8-,9?/m0/s1
SMILES Code
O=C(C1N(C([C@H](CC2=CNC=N2)N)=O)CCC1)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 251.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: O'Connor B, O'Cuinn G. Post-proline dipeptidyl-aminopeptidase from synaptosomal membranes of guinea-pig brain. A possible role for this activity in the hydrolysis of His-ProNH2, arising from the action of synaptosomal membrane pyroglutamate aminopeptidase on thyroliberin. Eur J Biochem. 1986 Jan 15;154(2):329-35. PubMed PMID: 2867901. 2: Browne P, O'Cuinn G. An evaluation of the role of a pyroglutamyl peptidase, a post-proline cleaving enzyme and a post-proline dipeptidyl amino peptidase, each purified from the soluble fraction of guinea-pig brain, in the degradation of thyroliberin in vitro. Eur J Biochem. 1983 Dec 1;137(1-2):75-87. PubMed PMID: 6140164. 3: Matsui T, Prasad C, Peterkofsky A. Metabolism of thyrotropin releasing hormone in brain extracts. Isolation and characterization of an imidopeptidase for histidylprolineamide. J Biol Chem. 1979 Apr 10;254(7):2439-45. PubMed PMID: 107159.