Levocarnitine chloride | CAS#6645-46-1 | quaternary amine

MedKoo Cat#: 596460 | Name: Levocarnitine chloride

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Carnitine is a quaternary amine that occurs naturally in most mammalian tissue. It is present in relatively high concentrations in skeletal muscle and heart where it is involved in regulating energy metabolism. It shifts glucose metabolism from glycolysis to glycogen storage and enhances the transport of long chain fatty acids into the mitochondria where they are oxidized for energy production. Carnitine is biosynthesized from lysine. It might be associated with the energy production from branched chain amino acids. L-Carnitine hydrochloride has been used to study ergothioneine transporter SLC22A4 and carnitine transporter SLC22A5. It has also been used to allow the entry of palmitic acid into the mitochondria.

Chemical Structure

Levocarnitine chloride

CAS#6645-46-1

Theoretical Analysis

MedKoo Cat#: 596460

Name: Levocarnitine chloride

CAS#: 6645-46-1

Chemical Formula: C7H16ClNO3

Exact Mass:

Molecular Weight: 197.66

Elemental Analysis: C, 42.54; H, 8.16; Cl, 17.93; N, 7.09; O, 24.28

Price and Availability

Size	Price	Availability	Quantity
25g	USD 250.00	2 Weeks
100g	USD 450.00	2 Weeks

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Related CAS #

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Synonym

Levocarnitine chloride; (R)-Carnitine hydrochloride; L-Carnitine chloride; L-Carnitine hydrochloride; LC-80; LC 80; LC80;

IUPAC/Chemical Name

(R)-3-carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride

InChi Key

JXXCENBLGFBQJM-FYZOBXCZSA-N

InChi Code

InChI=1S/C7H15NO3.ClH/c1-8(2,3)5-6(9)4-7(10)11;/h6,9H,4-5H2,1-3H3;1H/t6-;/m1./s1

SMILES Code

C[N+](C)(C)C[C@H](O)CC(O)=O.[Cl-]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

L-Carnitine hydrochloride ((R)-Carnitine hydrochloride), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway.

In vitro activity:

In the following, cells were treated with LC (L-Carnitine) and at the end of the treatment period, the cells were subjected to the real-time PCR technique along with western blotting assay for measurement of the telomere length and assessment of protein expression, respectively. The results showed that 0.2 mM LC caused the elongation of the telomere length and increased the TERT protein expression. Reference: Curr Stem Cell Res Ther. 2022 May 11. https://pubmed.ncbi.nlm.nih.gov/35546751/

In vivo activity:

Inflammation at the tissue level was also mildest in group A, and severest in the group that was not given carnitine (group C). All of the study groups and the control group differed significantly with respect to inflammation scores. In conclusion, L-carnitine improved oxygen saturation, and decreased urine leukotriene E4 levels and inflammation in lung tissues in the present murine model of asthma. Reference: Acta Med Okayama. 2002 Dec;56(6):295-301. https://pubmed.ncbi.nlm.nih.gov/12685858/

	Solvent	mg/mL	mM
Solubility
	Water	250.0	1,264.80

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 197.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Fathi E, Montazersaheb S, Sanaat Z, Nakhlband A, Vandghanooni S, Farahzadi R, Vietor I. L-carnitine reduced cellular aging of bone marrow resident C-kit+ hematopoietic stem cells through telomere dependent pathways. Curr Stem Cell Res Ther. 2022 May 11. doi: 10.2174/1574888X17666220511141123. Epub ahead of print. PMID: 35546751. 2. Lee YG, Chou HC, Chen YT, Tung SY, Ko TL, Buyandelger B, Wen LL, Juan SH. L-Carnitine reduces reactive oxygen species/endoplasmic reticulum stress and maintains mitochondrial function during autophagy-mediated cell apoptosis in perfluorooctanesulfonate-treated renal tubular cells. Sci Rep. 2022 Mar 18;12(1):4673. doi: 10.1038/s41598-022-08771-3. PMID: 35304586; PMCID: PMC8933466. 3. Dehghani A, Pourjafari F, Koohkan F, Haghpanh T, Pourjafari F, Sheibani V, Afarinesh MR. L-carnitine attenuates acoustic startle reflex dysfunction in adult male rats exposed to mancozeb. Toxicol Ind Health. 2023 Jan 17:7482337231151739. doi: 10.1177/07482337231151739. Epub ahead of print. PMID: 36650049. 4. Uzuner N, Kavukçu S, Yilmaz O, Ozkal S, Işlekel H, Karaman O, Soylu A, Kargi A. The role of L-carnitine in treatment of a murine model of asthma. Acta Med Okayama. 2002 Dec;56(6):295-301. doi: 10.18926/AMO/31692. PMID: 12685858.

In vitro protocol:

In vivo protocol:

1. Dehghani A, Pourjafari F, Koohkan F, Haghpanh T, Pourjafari F, Sheibani V, Afarinesh MR. L-carnitine attenuates acoustic startle reflex dysfunction in adult male rats exposed to mancozeb. Toxicol Ind Health. 2023 Jan 17:7482337231151739. doi: 10.1177/07482337231151739. Epub ahead of print. PMID: 36650049. 2. Uzuner N, Kavukçu S, Yilmaz O, Ozkal S, Işlekel H, Karaman O, Soylu A, Kargi A. The role of L-carnitine in treatment of a murine model of asthma. Acta Med Okayama. 2002 Dec;56(6):295-301. doi: 10.18926/AMO/31692. PMID: 12685858.

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