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MedKoo Cat#: 591277 | Name: AF-398

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AF-398 is a biochemical.

Chemical Structure

AF-398
AF-398
CAS#60439-45-4

Theoretical Analysis

MedKoo Cat#: 591277

Name: AF-398

CAS#: 60439-45-4

Chemical Formula: C18H27NO6

Exact Mass: 353.1838

Molecular Weight: 353.42

Elemental Analysis: C, 61.17; H, 7.70; N, 3.96; O, 27.16

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AF-398; AF 398; AF398;
IUPAC/Chemical Name
Benzoic acid, 3,4,5-trimethoxy-, 1-methyl-3-morpholinopropyl ester
InChi Key
HGLBNWHEUMEGLM-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H27NO6/c1-13(5-6-19-7-9-24-10-8-19)25-18(20)14-11-15(21-2)17(23-4)16(12-14)22-3/h11-13H,5-10H2,1-4H3
SMILES Code
O=C(OC(C)CCN1CCOCC1)C2=CC(OC)=C(OC)C(OC)=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 353.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Raisch TB, Yanoff MS, Larsen TR, Farooqui MA, King DR, Veeraraghavan R, Gourdie RG, Baker JW, Arnold WS, AlMahameed ST, Poelzing S. Intercalated Disk Extracellular Nanodomain Expansion in Patients With Atrial Fibrillation. Front Physiol. 2018 May 4;9:398. doi: 10.3389/fphys.2018.00398. eCollection 2018. PubMed PMID: 29780324; PubMed Central PMCID: PMC5945828. 2: Xue X, Jiang L, Duenninger E, Muenzel M, Guan S, Fazakas A, Cheng F, Illnitzky J, Keil T, Yu J. Impact of chronic kidney disease on Watchman implantation: experience with 300 consecutive left atrial appendage closures at a single center. Heart Vessels. 2018 Mar 22. doi: 10.1007/s00380-018-1157-x. [Epub ahead of print] PubMed PMID: 29564543. 3: Düzel B, Emren SV, Berilgen R. Effect of Atrial Fibrillation on Contrast-Induced Nephropathy Development in Patients With Non-ST-Segment Elevation Myocardial Infarction. Angiology. 2017 Nov;68(10):871-876. doi: 10.1177/0003319717699328. Epub 2017 Mar 21. PubMed PMID: 28956474. 4: Jakobsen M, Kolodziejczyk C, Klausen Fredslund E, Poulsen PB, Dybro L, Paaske Johnsen S. Costs of major intracranial, gastrointestinal and other bleeding events in patients with atrial fibrillation - a nationwide cohort study. BMC Health Serv Res. 2017 Jun 12;17(1):398. doi: 10.1186/s12913-017-2331-z. Erratum in: BMC Health Serv Res. 2017 Oct 9;17 (1):690. PubMed PMID: 28606079; PubMed Central PMCID: PMC5469002. 5: Boriani G, Tukkie R, Biffi M, Mont L, Ricci R, Pürerfellner H, Botto GL, Manolis AS, Landolina M, Gulizia M, Hudnall JH, Mangoni L, Grammatico A, Padeletti L; MINERVA Investigators. Atrial antitachycardia pacing and atrial remodeling: A substudy of the international, randomized MINERVA trial. Heart Rhythm. 2017 Oct;14(10):1476-1484. doi: 10.1016/j.hrthm.2017.05.023. Epub 2017 May 12. PubMed PMID: 28506917. 6: Coll-Vinent B, Martín A, Sánchez J, Tamargo J, Suero C, Malagón F, Varona M, Cancio M, Sánchez S, Carbajosa J, Ríos J, Casanovas G, Ràfols C, Del Arco C; EMERG-AF Investigators. Benefits of Emergency Departments' Contribution to Stroke Prophylaxis in Atrial Fibrillation: The EMERG-AF Study (Emergency Department Stroke Prophylaxis and Guidelines Implementation in Atrial Fibrillation). Stroke. 2017 May;48(5):1344-1352. doi: 10.1161/STROKEAHA.116.014855. Epub 2017 Apr 7. PubMed PMID: 28389612; PubMed Central PMCID: PMC5404399. 7: Zweiker D, Fröschl M, Tiede S, Weidinger P, Schmid J, Manninger M, Brussee H, Zweiker R, Binder J, Mächler H, Marte W, Maier R, Luha O, Schmidt A, Scherr D. Atrial fibrillation in transcatheter aortic valve implantation patients: Incidence, outcome and predictors of new onset. J Electrocardiol. 2017 Jul - Aug;50(4):402-409. doi: 10.1016/j.jelectrocard.2017.02.013. Epub 2017 Feb 20. PubMed PMID: 28274541. 8: Masè M. Application of computer models on atrial fibrillation research. Minerva Cardioangiol. 2017 Aug;65(4):398-419. doi: 10.23736/S0026-4725.17.04363-8. Epub 2017 Feb 17. Review. PubMed PMID: 28215065. 9: Wachter R, Gröschel K, Gelbrich G, Hamann GF, Kermer P, Liman J, Seegers J, Wasser K, Schulte A, Jürries F, Messerschmid A, Behnke N, Gröschel S, Uphaus T, Grings A, Ibis T, Klimpe S, Wagner-Heck M, Arnold M, Protsenko E, Heuschmann PU, Conen D, Weber-Krüger M; Find-AF(randomised) Investigators and Coordinators. Holter-electrocardiogram-monitoring in patients with acute ischaemic stroke (Find-AF(RANDOMISED)): an open-label randomised controlled trial. Lancet Neurol. 2017 Apr;16(4):282-290. doi: 10.1016/S1474-4422(17)30002-9. Epub 2017 Feb 8. PubMed PMID: 28187920. 10: Masri A, Kanj M, Thamilarasan M, Wazni O, Smedira NG, Lever HM, Desai MY. Outcomes in hypertrophic cardiomyopathy patients with and without atrial fibrillation: a survival meta-analysis. Cardiovasc Diagn Ther. 2017 Feb;7(1):36-44. doi: 10.21037/cdt.2016.11.23. PubMed PMID: 28164011; PubMed Central PMCID: PMC5253453. 11: Kochhäuser S, Alipour P, Haig-Carter T, Trought K, Hache P, Khaykin Y, Wulffhart Z, Pantano A, Tsang B, Birnie D, Verma A. Risk of Stroke and Recurrence After AF Ablation in Patients With an Initial Event-Free Period of 12 Months. J Cardiovasc Electrophysiol. 2017 Mar;28(3):273-279. doi: 10.1111/jce.13138. Epub 2017 Jan 11. PubMed PMID: 27933666. 12: Kim TH, Park J, Uhm JS, Kim JY, Joung B, Lee MH, Pak HN. Challenging Achievement of Bidirectional Block After Linear Ablation Affects the Rhythm Outcome in Patients With Persistent Atrial Fibrillation. J Am Heart Assoc. 2016 Oct 10;5(10). pii: e003894. PubMed PMID: 27792644; PubMed Central PMCID: PMC5121491. 13: Otero L, Hidalgo P, González R, Morillo CA. Association of Cardiovascular Disease and Sleep Apnea at Different Altitudes. High Alt Med Biol. 2016 Dec;17(4):336-341. Epub 2016 Aug 16. PubMed PMID: 27529440. 14: Hsu JC, Maddox TM, Kennedy K, Katz DF, Marzec LN, Lubitz SA, Gehi AK, Turakhia MP, Marcus GM. Aspirin Instead of Oral Anticoagulant Prescription in Atrial Fibrillation Patients at Risk for Stroke. J Am Coll Cardiol. 2016 Jun 28;67(25):2913-23. doi: 10.1016/j.jacc.2016.03.581. PubMed PMID: 27339487. 15: Kimura H, Nagasawa K, Tsukagoshi H, Matsushima Y, Fujita K, Yoshida LM, Tanaka R, Ishii H, Shimojo N, Kuroda M, Ryo A. Molecular evolution of the fusion protein gene in human respiratory syncytial virus subgroup A. Infect Genet Evol. 2016 Sep;43:398-406. doi: 10.1016/j.meegid.2016.06.019. Epub 2016 Jun 9. PubMed PMID: 27291709. 16: Kumar A, Kapoor A, Kumar S. An unusual case of hematuria in a young female: renal artery embolism, mitral stenosis, and sinus rhythm. Saudi J Kidney Dis Transpl. 2016 Mar;27(2):398-401. doi: 10.4103/1319-2442.178580. PubMed PMID: 26997399. 17: Wilbring M, Jung F, Weber C, Matschke K, Knaut M. Reduced Incidence of Thromboembolic Events After Surgical Closure of Left Atrial Appendage in Patients With Atrial Fibrillation. Innovations (Phila). 2016 Jan-Feb;11(1):24-30; discussion 30. doi: 10.1097/IMI.0000000000000231. PubMed PMID: 26914669. 18: Patel N, Ju C, Macon C, Thadani U, Schulte PJ, Hernandez AF, Bhatt DL, Butler J, Yancy CW, Fonarow GC. Temporal Trends of Digoxin Use in Patients Hospitalized With Heart Failure: Analysis From the American Heart Association Get With The Guidelines-Heart Failure Registry. JACC Heart Fail. 2016 May;4(5):348-56. doi: 10.1016/j.jchf.2015.12.003. Epub 2016 Feb 10. PubMed PMID: 26874392. 19: Kuang P, Mah ND, Barton CA, Miura AJ, Tanas LR, Ran R. Achieving ventricular rate control using metoprolol in β-blocker-naive patients vs patients on chronic β-blocker therapy. Am J Emerg Med. 2016 Mar;34(3):606-8. doi: 10.1016/j.ajem.2015.12.084. Epub 2016 Jan 7. PubMed PMID: 26830391. 20: Kališnik JM, Hrovat E, Hrastovec A, Avbelj V, Žibert J, Geršak B. Severe Cardiac Autonomic Derangement and Altered Ventricular Repolarization Pave the Way to Postoperative Atrial Fibrillation. Innovations (Phila). 2015 Nov-Dec;10(6):398-405. doi: 10.1097/IMI.0000000000000203. PubMed PMID: 26680751.