MedKoo Cat#: 591276 | Name: AF 14

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AF 14 is a biochemical.

Chemical Structure

AF 14
AF 14
CAS#60375-43-1

Theoretical Analysis

MedKoo Cat#: 591276

Name: AF 14

CAS#: 60375-43-1

Chemical Formula: C17H21NO

Exact Mass: 255.1623

Molecular Weight: 255.36

Elemental Analysis: C, 79.96; H, 8.29; N, 5.49; O, 6.27

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AF 14; AF-14; AF14;
IUPAC/Chemical Name
2H-1,4-Ethanoquinolin-6(5H)-one, hexahydro-7-phenyl-
InChi Key
FLBXKBCYSKRFEN-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H21NO/c19-17-11-14-13-6-8-18(9-7-13)16(14)10-15(17)12-4-2-1-3-5-12/h1-5,13-16H,6-11H2
SMILES Code
O=C1CC2C(CC3)CCN3C2CC1C4=CC=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 255.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Herold J, Herold-Vlanti V, Sherif M, Luani B, Breyer C, Bonaventura K, Braun-Dullaeus R. Analysis of cardiovascular mortality, bleeding, vascular and cerebrovascular events in patients with atrial fibrillation vs. sinus rhythm undergoing transfemoral Transcatheter Aortic Valve Implantation (TAVR). BMC Cardiovasc Disord. 2017 Dec 20;17(1):298. doi: 10.1186/s12872-017-0736-6. PubMed PMID: 29262768; PubMed Central PMCID: PMC5738713. 2: Gorter TM, van Melle JP, Rienstra M, Borlaug BA, Hummel YM, van Gelder IC, Hoendermis ES, Voors AA, van Veldhuisen DJ, Lam CSP. Right Heart Dysfunction in Heart Failure With Preserved Ejection Fraction: The Impact of Atrial Fibrillation. J Card Fail. 2018 Mar;24(3):177-185. doi: 10.1016/j.cardfail.2017.11.005. Epub 2017 Nov 29. PubMed PMID: 29197548. 3: Airy M, Chang TI, Ding VY, Goldstein BA, Bansal N, Niu J, Navaneethan SD, Turakhia MP, Winkelmayer WC. Risk profiles for acute health events after incident atrial fibrillation in patients with end-stage renal disease on hemodialysis. Nephrol Dial Transplant. 2017 Nov 13. doi: 10.1093/ndt/gfx301. [Epub ahead of print] PubMed PMID: 29145634. 4: Akanksha WG, Paramdeep K, Gagandeep S, Rajinder B, Birinder SP, Monika S, Shavinder S, Clarence JS, Shweta JV, Sharma M, Jeyaraj DP. Clinical Features, Risk Factors, and Short-term Outcome of Ischemic Stroke, in Patients with Atrial Fibrillation: Data from a Population-based Study. Ann Indian Acad Neurol. 2017 Jul-Sep;20(3):289-293. doi: 10.4103/aian.AIAN_16_17. PubMed PMID: 28904464; PubMed Central PMCID: PMC5586127. 5: Ondrakova M, Motovska Z, Waldauf P, Knot J, Havluj L, Bittner L, Bartoska R, Gűrlich R, Krbec M, Dzupa V, Grill R, Widimsky P. Antithrombotic therapy of patients with atrial fibrillation discharged after major non-cardiac surgery. 1-year follow-up. Sub-analysis of PRAGUE 14 study. PLoS One. 2017 May 24;12(5):e0177519. doi: 10.1371/journal.pone.0177519. eCollection 2017. PubMed PMID: 28542316; PubMed Central PMCID: PMC5443499. 6: Reading SR, Go AS, Fang MC, Singer DE, Liu IA, Black MH, Udaltsova N, Reynolds K; Anticoagulation and Risk Factors in Atrial Fibrillation–Cardiovascular Research Network (ATRIA‐CVRN) Investigators. Health Literacy and Awareness of Atrial Fibrillation. J Am Heart Assoc. 2017 Apr 11;6(4). pii: e005128. doi: 10.1161/JAHA.116.005128. PubMed PMID: 28400367; PubMed Central PMCID: PMC5533014. 7: Balouch M, Gucuk Ipek E, Chrispin J, Bajwa RJ, Zghaib T, Berger RD, Ashikaga H, Nazarian S, Marine JE, Calkins H, Spragg DD. Impact of rotor temperospatial stability on acute and one-year atrial fibrillation ablation outcomes. Clin Cardiol. 2017 Jun;40(6):383-389. doi: 10.1002/clc.22674. Epub 2017 Jan 25. PubMed PMID: 28120392. 8: Anczykowski J, Willems S, Hoffmann BA, Meinertz T, Blankenberg S, Patten M. Early Detection of Symptomatic Paroxysmal Cardiac Arrhythmias by Trans-Telephonic ECG Monitoring: Impact on Diagnosis and Treatment of Atrial Fibrillation. J Cardiovasc Electrophysiol. 2016 Sep;27(9):1032-7. doi: 10.1111/jce.13025. Epub 2016 Jun 30. PubMed PMID: 27257094. 9: Faselis C, Kokkinos P, Tsimploulis A, Pittaras A, Myers J, Lavie CJ, Kyritsi F, Lovic D, Karasik P, Moore H. Exercise Capacity and Atrial Fibrillation Risk in Veterans: A Cohort Study. Mayo Clin Proc. 2016 May;91(5):558-66. doi: 10.1016/j.mayocp.2016.03.002. Epub 2016 Apr 8. PubMed PMID: 27068670. 10: Yamabe H, Kanazawa H, Itoh M, Kaneko S, Ogawa H. Difference in the maintenance mechanism of atrial fibrillation perpetuated after pulmonary vein isolation between paroxysmal and persistent atrial fibrillation: Effects of subsequent stepwise ablation. Int J Cardiol. 2016 May 1;210:109-18. doi: 10.1016/j.ijcard.2016.02.092. Epub 2016 Feb 19. PubMed PMID: 26938685. 11: Diouf I, Magliano DJ, Carrington MJ, Stewart S, Shaw JE. Prevalence, incidence, risk factors and treatment of atrial fibrillation in Australia: The Australian Diabetes, Obesity and Lifestyle (AusDiab) longitudinal, population cohort study. Int J Cardiol. 2016 Feb 15;205:127-132. doi: 10.1016/j.ijcard.2015.12.013. Epub 2015 Dec 15. PubMed PMID: 26730844. 12: Velagic V, DE Asmundis C, Mugnai G, Irfan G, Hunuk B, Stroker E, Hacioglu E, Umbrain V, Beckers S, Czapla J, Wellens F, Nijs J, Brugada P, LA Meir M, Chierchia GB. Repeat Procedures After Hybrid Thoracoscopic Ablation in the Setting of Longstanding Persistent Atrial Fibrillation: Electrophysiological Findings and 2-Year Clinical Outcome. J Cardiovasc Electrophysiol. 2016 Jan;27(1):41-50. doi: 10.1111/jce.12837. Epub 2015 Nov 13. PubMed PMID: 26374195. 13: Palomäki A, Mustonen P, Hartikainen JE, Nuotio I, Kiviniemi T, Ylitalo A, Hartikainen P, Airaksinen KE. Underuse of anticoagulation in stroke patients with atrial fibrillation--the FibStroke Study. Eur J Neurol. 2016 Jan;23(1):133-9. doi: 10.1111/ene.12820. Epub 2015 Aug 11. PubMed PMID: 26263442. 14: Krumkamp R, Sarpong N, Schwarz NG, Adlkofer J, Loag W, Eibach D, Hagen RM, Adu-Sarkodie Y, Tannich E, May J. Gastrointestinal infections and diarrheal disease in Ghanaian infants and children: an outpatient case-control study. PLoS Negl Trop Dis. 2015 Mar 4;9(3):e0003568. doi: 10.1371/journal.pntd.0003568. eCollection 2015 Mar. Erratum in: PLoS Negl Trop Dis. 2015 Apr;9(4):e0003728. Adelkofer, Julia [corrected to Adlkofer, Julia]. PubMed PMID: 25738935; PubMed Central PMCID: PMC4349824. 15: Blustin JM, McBane RD, Mazur M, Ammash N, Sochor O, Grill DE, Wysokinski WE. The association between thromboembolic complications and blood group in patients with atrial fibrillation. Mayo Clin Proc. 2015 Feb;90(2):216-23. doi: 10.1016/j.mayocp.2014.11.013. PubMed PMID: 25659240. 16: Denoël P, Vanderstraeten J, Mols P, Pepersack T. Could some geriatric characteristics hinder the prescription of anticoagulants in atrial fibrillation in the elderly? J Aging Res. 2014;2014:693740. doi: 10.1155/2014/693740. Epub 2014 Sep 10. PubMed PMID: 25295192; PubMed Central PMCID: PMC4175391. 17: Pham-Duc P, Nguyen-Viet H, Hattendorf J, Cam PD, Zurbrügg C, Zinsstag J, Odermatt P. Diarrhoeal diseases among adult population in an agricultural community Hanam province, Vietnam, with high wastewater and excreta re-use. BMC Public Health. 2014 Sep 20;14:978. doi: 10.1186/1471-2458-14-978. PubMed PMID: 25239151; PubMed Central PMCID: PMC4180152. 18: Ullah W, Hunter RJ, Baker V, Dhinoja MB, Sporton S, Earley MJ, Schilling RJ. Factors affecting catheter contact in the human left atrium and their impact on ablation efficacy. J Cardiovasc Electrophysiol. 2015 Feb;26(2):129-36. doi: 10.1111/jce.12542. Epub 2014 Oct 14. PubMed PMID: 25213917. 19: Scaglione M, Gallo C, Battaglia A, Sardi D, Gaido L, Anselmino M, Garberoglio L, Giustetto C, Castagno D, Ferraris F, Toso E, Gaita F. Long-term progression from paroxysmal to permanent atrial fibrillation following transcatheter ablation in a large single-center experience. Heart Rhythm. 2014 May;11(5):777-82. doi: 10.1016/j.hrthm.2014.02.018. Epub 2014 Feb 19. PubMed PMID: 24561164. 20: Mahaffey KW, Stevens SR, White HD, Nessel CC, Goodman SG, Piccini JP, Patel MR, Becker RC, Halperin JL, Hacke W, Singer DE, Hankey GJ, Califf RM, Fox KA, Breithardt G; ROCKET AF Investigators. Ischaemic cardiac outcomes in patients with atrial fibrillation treated with vitamin K antagonism or factor Xa inhibition: results from the ROCKET AF trial. Eur Heart J. 2014 Jan;35(4):233-41. doi: 10.1093/eurheartj/eht428. Epub 2013 Oct 15. PubMed PMID: 24132190; PubMed Central PMCID: PMC3896862.