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MedKoo Cat#: 596413 | Name: Ornithine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ornithine is an amino acid produced in the urea cycle by the splitting off of urea from arginine.

Chemical Structure

Ornithine
Ornithine
CAS#70-26-8

Theoretical Analysis

MedKoo Cat#: 596413

Name: Ornithine

CAS#: 70-26-8

Chemical Formula: C5H12N2O2

Exact Mass: 132.0899

Molecular Weight: 132.16

Elemental Analysis: C, 45.44; H, 9.15; N, 21.20; O, 24.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ornithine; Ornithinum; BRN 1722298; BRN-1722298; BRN1722298; L(-)-Ornithine;
IUPAC/Chemical Name
(S)-2,5-diaminopentanoic acid
InChi Key
AHLPHDHHMVZTML-BYPYZUCNSA-N
InChi Code
InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)/t4-/m0/s1
SMILES Code
N[C@@H](CCCN)C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 132.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Goh ET, Stokes CS, Sidhu SS, Vilstrup H, Gluud LL, Morgan MY. L-ornithine L-aspartate for prevention and treatment of hepatic encephalopathy in people with cirrhosis. Cochrane Database Syst Rev. 2018 May 15;5:CD012410. doi: 10.1002/14651858.CD012410.pub2. [Epub ahead of print] Review. PubMed PMID: 29762873. 2: Harris S, Vora NL. Maternal Genetic Disorders in Pregnancy. Obstet Gynecol Clin North Am. 2018 Jun;45(2):249-265. doi: 10.1016/j.ogc.2018.01.010. Review. PubMed PMID: 29747729. 3: Holzmuller P, Geiger A, Nzoumbou-Boko R, Pissarra J, Hamrouni S, Rodrigues V, Dauchy FA, Lemesre JL, Vincendeau P, Bras-Gonçalves R. Trypanosomatid Infections: How Do Parasites and Their Excreted-Secreted Factors Modulate the Inducible Metabolism of l-Arginine in Macrophages? Front Immunol. 2018 Apr 20;9:778. doi: 10.3389/fimmu.2018.00778. eCollection 2018. Review. PubMed PMID: 29731753; PubMed Central PMCID: PMC5921530. 4: Kornerup LS, Gluud LL, Vilstrup H, Dam G. 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PubMed PMID: 29517999; PubMed Central PMCID: PMC5872179. 8: Summar ML, Mew NA. Inborn Errors of Metabolism with Hyperammonemia: Urea Cycle Defects and Related Disorders. Pediatr Clin North Am. 2018 Apr;65(2):231-246. doi: 10.1016/j.pcl.2017.11.004. Epub 2018 Feb 2. Review. PubMed PMID: 29502911. 9: LoGiudice N, Le L, Abuan I, Leizorek Y, Roberts SC. Alpha-Difluoromethylornithine, an Irreversible Inhibitor of Polyamine Biosynthesis, as a Therapeutic Strategy against Hyperproliferative and Infectious Diseases. Med Sci (Basel). 2018 Feb 8;6(1). pii: E12. doi: 10.3390/medsci6010012. Review. PubMed PMID: 29419804; PubMed Central PMCID: PMC5872169. 10: Glycerol Phenylbutyrate (Ravicti) [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2017 Apr. Available from http://www.ncbi.nlm.nih.gov/books/NBK476300/ PubMed PMID: 29381293. 11: Muxel SM, Aoki JI, Fernandes JCR, Laranjeira-Silva MF, Zampieri RA, Acuña SM, Müller KE, Vanderlinde RH, Floeter-Winter LM. Arginine and Polyamines Fate in Leishmania Infection. Front Microbiol. 2018 Jan 15;8:2682. doi: 10.3389/fmicb.2017.02682. eCollection 2017. Review. PubMed PMID: 29379478; PubMed Central PMCID: PMC5775291. 12: Bryson TE, Anglin CM, Bridges PH, Cottle RN. Nuclease-Mediated Gene Therapies for Inherited Metabolic Diseases of the Liver. Yale J Biol Med. 2017 Dec 19;90(4):553-566. eCollection 2017 Dec. Review. PubMed PMID: 29259521; PubMed Central PMCID: PMC5733857. 13: Murray-Stewart T, Casero RA. Regulation of Polyamine Metabolism by Curcumin for Cancer Prevention and Therapy. Med Sci (Basel). 2017 Dec 18;5(4). pii: E38. doi: 10.3390/medsci5040038. Review. PubMed PMID: 29258259; PubMed Central PMCID: PMC5753667. 14: Sivolap YP. [Prevention and treatment of hepatic encephalopathy]. Zh Nevrol Psikhiatr Im S S Korsakova. 2017;117(10):144-147. doi: 10.17116/jnevro2017117101144-147. Review. Russian. PubMed PMID: 29171503. 15: Papadia C, Osowska S, Cynober L, Forbes A. Citrulline in health and disease. Review on human studies. Clin Nutr. 2017 Oct 16. pii: S0261-5614(17)31369-9. doi: 10.1016/j.clnu.2017.10.009. [Epub ahead of print] Review. PubMed PMID: 29107336. 16: Wasim M, Awan FR, Khan HN, Tawab A, Iqbal M, Ayesha H. Aminoacidopathies: Prevalence, Etiology, Screening, and Treatment Options. Biochem Genet. 2018 Apr;56(1-2):7-21. doi: 10.1007/s10528-017-9825-6. Epub 2017 Nov 1. Review. PubMed PMID: 29094226. 17: Zimmer AM, Wright PA, Wood CM. Ammonia and urea handling by early life stages of fishes. J Exp Biol. 2017 Nov 1;220(Pt 21):3843-3855. doi: 10.1242/jeb.140210. Review. PubMed PMID: 29093184. 18: McCully KS. Hyperhomocysteinemia, Suppressed Immunity, and Altered Oxidative Metabolism Caused by Pathogenic Microbes in Atherosclerosis and Dementia. Front Aging Neurosci. 2017 Oct 6;9:324. doi: 10.3389/fnagi.2017.00324. eCollection 2017. Review. PubMed PMID: 29056905; PubMed Central PMCID: PMC5635055. 19: Weiss N, Mochel F, Rudler M, Demeret S, Lebray P, Conti F, Galanaud D, Ottolenghi C, Bonnefont JP, Dommergues M, Bernuau J, Thabut D. Peak hyperammonemia and atypical acute liver failure: The eruption of an urea cycle disorder during hyperemesis gravidarum. J Hepatol. 2017 Sep 20. pii: S0168-8278(17)32289-4. doi: 10.1016/j.jhep.2017.09.009. [Epub ahead of print] Review. PubMed PMID: 28939132. 20: Bigot A, Tchan MC, Thoreau B, Blasco H, Maillot F. Liver involvement in urea cycle disorders: a review of the literature. J Inherit Metab Dis. 2017 Nov;40(6):757-769. doi: 10.1007/s10545-017-0088-5. Epub 2017 Sep 12. Review. PubMed PMID: 28900784.