Synonym
Dienone B; NSC 289074; NSC-289074; NSC289074
IUPAC/Chemical Name
2,5-Cyclohexadiene-1-acetamide, 3,5-dibromo-1-hydroxy-4-oxo-
InChi Key
OPJJYFWUWHEWDE-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H7Br2NO3/c9-4-1-8(14,3-6(11)12)2-5(10)7(4)13/h1-2,14H,3H2,(H2,11,12)
SMILES Code
O=C(N)CC1(O)C=C(Br)C(C(Br)=C1)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
324.96
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Koulman A, Proksch P, Ebel R, Beekman AC, van Uden W, Konings AW, Pedersen JA, Pras N, Woerdenbag HJ. Cytotoxicity and mode of action of aeroplysinin-1 and a related dienonefrom the sponge Aplysina aerophoba. J Nat Prod. 1996 Jun;59(6):591-4. PubMed PMID: 8786366.
2: Kreuter MH, Robitzki A, Chang S, Steffen R, Michaelis M, Kljajić Z, Bachmann M, Schröder HC, Müller WE. Production of the cytostatic agent aeroplysinin by the sponge Verongia aerophoba in in vitro culture. Comp Biochem Physiol C. 1992;101(1):183-7. PubMed PMID: 1350964.
3: Gorshkova IA, Gorshkov BA, Makar'eva TN, Stonik VA, Zamaraeva MV. [Characteristics of the inhibiting action of dienone B on adenosine triphosphatase activity]. Izv Akad Nauk SSSR Biol. 1988 Sep-Oct;(5):676-82. Russian. PubMed PMID: 2849614.
