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MedKoo Cat#: 596408 | Name: Ricinoleic acid
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ricinoleic acid is a fatty acid. It constitutes about 90% of the fatty acids in castor oil. Ricinoleic acid can serve as a substrate for the synthesis of conjugated linoleic acids. It is considered safe and non-toxic as a food constituent in humans, up to a daily intake of 2.5 grams per day. In high doses, castor oil has a laxative effect.

Chemical Structure

Ricinoleic acid
Ricinoleic acid
CAS#141-22-0

Theoretical Analysis

MedKoo Cat#: 596408

Name: Ricinoleic acid

CAS#: 141-22-0

Chemical Formula: C18H34O3

Exact Mass: 298.2508

Molecular Weight: 298.46

Elemental Analysis: C, 72.44; H, 11.48; O, 16.08

Price and Availability

Size Price Availability Quantity
100mg USD 300.00
1g USD 700.00
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Related CAS #
No Data
Synonym
Ricinoleic acid; Castor oil acid; Acide ricinoleique; Kyselina ricinolova; NSC 281242; NSC-281242; NSC281242;
IUPAC/Chemical Name
(R,Z)-12-hydroxyoctadec-9-enoic acid
InChi Key
WBHHMMIMDMUBKC-QJWNTBNXSA-N
InChi Code
InChI=1S/C18H34O3/c1-2-3-4-11-14-17(19)15-12-9-7-5-6-8-10-13-16-18(20)21/h9,12,17,19H,2-8,10-11,13-16H2,1H3,(H,20,21)/b12-9-/t17-/m1/s1
SMILES Code
CCCCCC[C@@H](O)C/C=C\CCCCCCCC(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
L-Ribulose is an isomer of L-ribose.
In vitro activity:
The results from the in vitro study showed that the blank ricinoleic acid pluronic lecithin organogel (PLO) gel possessed significantly higher anti-inflammatory activity than isopropyl palmitate PLO gel. Both the gel formulations had no significant cytotoxic activity. Reference: Mediators Inflamm. 2000;9(5):223-8. https://pubmed.ncbi.nlm.nih.gov/11200362/
In vivo activity:
Ricinoleic acid and capsaicin given for 1-3 weeks reduced inflammation induced by intradermal injection of carrageenan in the mouse or by histamine in the guinea-pig eyelid. Ricinoleic acid may be seen as a new capsaicin-like, non-pungent anti-inflammatory agent suitable for peripheral application. Reference: Int J Pharm. 2015 Feb 1;479(1):207-11. https://pubmed.ncbi.nlm.nih.gov/25542985/

Preparing Stock Solutions

The following data is based on the product molecular weight 298.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Boddu SH, Alsaab H, Umar S, Bonam SP, Gupta H, Ahmed S. Anti-inflammatory effects of a novel ricinoleic acid poloxamer gel system for transdermal delivery. Int J Pharm. 2015 Feb 1;479(1):207-11. doi: 10.1016/j.ijpharm.2014.12.051. Epub 2014 Dec 24. PMID: 25542985. 2. Boddu SH, Bonam SP, Wei Y, Alexander K. Preparation and in vitro evaluation of a pluronic lecithin organogel containing ricinoleic acid for transdermal delivery. Int J Pharm Compd. 2014 May-Jun;18(3):256-61. PMID: 25306775. 3. Tunaru S, Althoff TF, Nüsing RM, Diener M, Offermanns S. Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors. Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9179-84. doi: 10.1073/pnas.1201627109. Epub 2012 May 21. PMID: 22615395; PMCID: PMC3384204. 4. Vieira C, Evangelista S, Cirillo R, Lippi A, Maggi CA, Manzini S. Effect of ricinoleic acid in acute and subchronic experimental models of inflammation. Mediators Inflamm. 2000;9(5):223-8. doi: 10.1080/09629350020025737. PMID: 11200362; PMCID: PMC1781768.
In vitro protocol:
1. Boddu SH, Alsaab H, Umar S, Bonam SP, Gupta H, Ahmed S. Anti-inflammatory effects of a novel ricinoleic acid poloxamer gel system for transdermal delivery. Int J Pharm. 2015 Feb 1;479(1):207-11. doi: 10.1016/j.ijpharm.2014.12.051. Epub 2014 Dec 24. PMID: 25542985. 2. Boddu SH, Bonam SP, Wei Y, Alexander K. Preparation and in vitro evaluation of a pluronic lecithin organogel containing ricinoleic acid for transdermal delivery. Int J Pharm Compd. 2014 May-Jun;18(3):256-61. PMID: 25306775.
In vivo protocol:
1. Tunaru S, Althoff TF, Nüsing RM, Diener M, Offermanns S. Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors. Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9179-84. doi: 10.1073/pnas.1201627109. Epub 2012 May 21. PMID: 22615395; PMCID: PMC3384204. 2. Vieira C, Evangelista S, Cirillo R, Lippi A, Maggi CA, Manzini S. Effect of ricinoleic acid in acute and subchronic experimental models of inflammation. Mediators Inflamm. 2000;9(5):223-8. doi: 10.1080/09629350020025737. PMID: 11200362; PMCID: PMC1781768.
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