Synonym
Diethadione; Diethadionum; HSDB 5514; L 1811; L-1811; L1811; NSC 169418; NSC169418; NSC-169418;
IUPAC/Chemical Name
5,5-diethyl-1,3-oxazinane-2,4-dione
InChi Key
ORTYMGHCFWKXHO-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H13NO3/c1-3-8(4-2)5-12-7(11)9-6(8)10/h3-5H2,1-2H3,(H,9,10,11)
SMILES Code
O=C(N1)OCC(CC)(CC)C1=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
171.19
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lorizio A, Gandini S. [Inhibiting action of gamma-amino-butyrylcholine on convulsive crises and on electroencephalographic paroxysms evoked by diethadione, by hyperpnea and by intermittent light stimulation in epileptic subjects]. Riv Neurobiol. 1966 Apr-Jun;12(2):153-65. Italian. PubMed PMID: 4381273.
2: RADERMECKER M, MARCELLE R, PETIT JM, MELON J. [INFLUENCE OF A RESPIRATORY ANALEPTIC, DIETHADIONE, ON VENTILATORY MECHANICAL WORK AFTER SODIUM PENTOTHAL INJECTION]. Pathol Biol. 1964 Aug-Sep;12:859-63. French. PubMed PMID: 14200510.
3: FADIGA E, GESSI T, MAFFII G. [ELECTROPHYSIOLOGICAL RESEARCH ON THE ACTION OF AN OXAZINE-DIONE DERIVATIVE (DIETHADIONE) ON THE RESPIRATORY CENTERS]. Arch Sci Biol (Bologna). 1964 Apr-Jun;48:149-62. Italian. PubMed PMID: 14210398.
4: SFORZA I. [DIETHADIONE IN FLUOTHANE ANESTHESIA IN EXTRA-ABDOMINAL UROLOGICAL AND OPHTHALMIC SURGERY]. Acta Anaesthesiol. 1964 Mar-Apr;15:169-87. Italian. PubMed PMID: 14154986.
5: RADERMECKER M, MARCELLE R, DALIMIER N, OGER A. [INFLUENCE OF ORAL DIETHADIONE ADMINISTRATION ON THE HYPERCAPNIA OF THE CHRONIC PULMONARY PATIENT]. Acta Tuberc Pneumol Belg. 1964 Jan-Feb;55:33-41. French. PubMed PMID: 14175172.
6: VERNONI S. [THE USE OF 4-CHLOROTESTOSTERONE ACETATE AND OF DIETHADIONE IN PATIENTS WITH POSTOPERATIVE HYPOTENSION]. Riv Patol Clin. 1963 Aug;18:431-41. Italian. PubMed PMID: 14083555.
7: FASSINA G. [CLINICO-INSTRUMENTAL EVALUATION OF THE RESPIRATORY ANALEPTIC ACTION OF DIETHADIONE]. Gazz Int Med Chir. 1963 Jul 31;68:1496-511. Italian. PubMed PMID: 14047717.
8: CAZZOLA D, MORELLI V, ZORCOLO S. [ON THE CENTRAL STIMULATION OF RESPIRATION AND CIRCULATION IN GYNECOLOGICAL OPERATIONS AND OBSTRETRICS AND IN ASPHYXIA NEONATORUM. CLINICAL EXPERIENCE WITH DIETHADIONE]. Minerva Ginecol. 1963 Jun 15;15:559-63. Italian. PubMed PMID: 14047382.
9: WITTGENS A. [Tocen (diethadione): a new analeptic]. Boll Chim Farm. 1963 Feb;102:88-90. Italian. PubMed PMID: 14001416.
10: RIZZI R, NICOLIS FB. [Clinico-statistical considerations on some barbiturate antagonists with special reference to diethadione]. Sem Med. 1962 Oct 29;121:1635-45. Spanish. PubMed PMID: 13974174.
11: MARTINO OE. [Diethadione, a new analeptic]. Dia Med. 1962 May 7;34:660-2. Spanish. PubMed PMID: 14470538.
12: CALLIGARI G, ROSSI W, BARBIERI G. [Considerations on the use of diethadione in anesthesia]. Acta Anaesthesiol. 1962 May-Jun;13:207-21. Italian. PubMed PMID: 14017918.
13: DAMENO R. [Diethadione: a new analeptic. Its use in newborn infants]. Sem Med. 1962 Apr 16;120:703-4. Spanish. PubMed PMID: 13883288.
14: SANTIAGO CURCI A. [Clinical trials of diethadione]. Dia Med. 1962 Mar 19;34:320-2. Spanish. PubMed PMID: 14497046.
15: NICOLIS FB, ACOCELLA G, GHISELLINI A, CENACCHI G, ALBERTI G. A study of some pharmacological properties of diethadione in man. Chemotherapia (Basel). 1962;4:485-505. PubMed PMID: 14479573.
