Synonym
Medazomide; Medazomidum; L-1777; L 1777; L1777;
IUPAC/Chemical Name
1-methyl-6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxamide
InChi Key
LXFKHPXXAPOYCC-UHFFFAOYSA-N
InChi Code
InChI=1S/C6H9N3O2/c1-9-5(10)3-2-4(8-9)6(7)11/h2-3H2,1H3,(H2,7,11)
SMILES Code
O=C(C(CC1)=NN(C)C1=O)N
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
155.15
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lee JS, Wu R, Wong T, DuBois SG, Matthay K, Gustafson C, Hawkins R, Roy-Burman A. Extended Sedation With Continuous Midazolam or Dexmedetomidine Infusion for Young Children Receiving 131 I-MIBG Radiopharmaceutical Therapy for Advanced Neuroblastoma. Pediatr Blood Cancer. 2016 Mar;63(3):471-8. doi: 10.1002/pbc.25827. Epub 2015 Nov 19. PubMed PMID: 26585842.
2: Wutzler A, Mueller A, Loehr L, Huemer M, Parwani AS, Attanasio P, Blaschke F, Storm C, Boldt LH, Haverkamp W. Minimal and deep sedation during ablation of ventricular tachycardia. Int J Cardiol. 2014 Mar 1;172(1):161-4. doi: 10.1016/j.ijcard.2013.12.175. Epub 2014 Jan 8. PubMed PMID: 24447761.
3: Nosál'ová G, Strapková A, Korpás J. [Action of medazonamid on cough in an experiment]. Farmakol Toksikol. 1986 Jan-Feb;49(1):81-4. Russian. PubMed PMID: 3948994.
4: NICOLIS FB, PASQUARIELLO G. [Controlled clinical experiments with new antitussive drugs. I. Methodological considerations and evaluation of the antitussive activity of medazonamide]. Clin Ter. 1962 Aug 15;23:215-25. Italian. PubMed PMID: 13938444.
